LY 354740, Group II mGlu agonist (ab120173)
Key features and details
- Group II mGlu agonist. Systemically active.
- CAS Number: 176199-48-7
- Soluble in 1 eq. NaOH to 100 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
LY 354740, Group II mGlu agonist -
製品の詳細
Group II mGlu agonist. Systemically active. -
生理活性の詳細
Highly potent and selective agonist at mGlu2 and mGlu3 receptors (EC50 values are 5.1 and 24.3 nM, respectively). Displays no agonist or antagonist activity at mGlu1a, mGlu5a, mGlu4 or mGlu7 receptors at concentrations up to 100 μM. Orally and systemically active. Anxiolytic and antiaddictive effects in vivo.
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CAS 番号
176199-48-7 -
構造式
製品の特性
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体系名
(1S,2S,5R,6S)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid -
分子量
185.18 -
分子式
C8H11NO4 -
PubChem 登録番号
213056 -
保存方法
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in 1 eq. NaOH to 100 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
OC(=O)[C@]2(N)CC[C@H]1[C@H](C(=O)O)[C@H]12 -
由来
Synthetic
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研究分野
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (1)
ab120173 は 1 報の論文で使用されています。
- Procaccini C et al. Reversal of novelty-induced hyperlocomotion and hippocampal c-Fos expression in GluA1 knockout male mice by the mGluR2/3 agonist LY354740. Neuroscience 250:189-200 (2013). PubMed: 23867766