LY 344864 hydrochloride, 5-HT1F agonist (ab120592)
Key features and details
- Selective, potent 5-HT1F agonist
- CAS Number: 186544-26-3
- Purity: > 98%
- Soluble in DMSO to 100 mM and in water to 5 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
LY 344864 hydrochloride, 5-HT1F agonist -
製品の詳細
Selective, potent 5-HT1F agonist -
生理活性の詳細
Selective, potent, full 5-HT1F agonist (EC50 = 3 nM). Selectivity is 80-fold greater than for other 5-HT receptor subtypes, Ki values are 0.53 (5-HT1A), 0.549 (5-HT1B), 0.575 (5-HT1D), 1.415 (5-HT1E), 3.935 (5-HT2A), 1.695 (5-HT2B), 3.499 (5-HT2C) and 4.851 (5-HT7). Able to reduce central sensitization and dural inflammation in vivo.
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精製度
> 98% -
CAS 番号
186544-26-3 -
構造式
製品の特性
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体系名
N-[(3R)-3-(Dimethylamino)-2,3,4,9-tetrahydro-1H-carbazol-6-yl]-4-fluorobenzamide hydrochloride -
分子量
387.88 -
分子式
C21H22FN3O.HCl -
保存方法
Store at +4°C. The product can be stored for up to 12 months. -
溶解性
Soluble in DMSO to 100 mM and in water to 5 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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由来
Synthetic
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研究分野
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (1)
ab120592 は 1 報の論文で使用されています。
- Stantcheva KK et al. A subpopulation of itch-sensing neurons marked by Ret and somatostatin expression. EMBO Rep 17:585-600 (2016). PubMed: 26929027