製品の概要

  • 製品名

    LY 341495 disodium salt, group II/group III mGlu antagonist
  • 製品の詳細

    Water-soluble group II/group III mGlu antagonist. Disodium salt of LY 341495 (ab120199).
  • 生理活性の詳細

    Water-soluble and very selective nanomolar potent antagonist for group II mGlu receptors. Also a relatively potent antagonist for group III mGlu receptors at high nanomolar to low micromolar concentrations. Disodium salt of LY 341495 (ab120199) which displays Kd values of 1.67 (human mGlu2), 0.75 (mGlu3), 31.6 (mGlu6), 72.7 (mGlu7a) and 14 (human mGlu8a receptors) nM. LY 341495 displays IC50 values of 7.8, 8.2 and 22 μM for mGlu1a, mGlu5a and mGlu4 receptors, respectively. It is readily brain penetrant and active in vivo.

    Also available in simple stock solutions (ab144500) - add 1 ml of water to get an exact, ready-to-use concentration.
  • 精製度

    > 98%
  • 構造式

    Chemical Structure

製品の特性

参考文献

ab120818 has not yet been referenced specifically in any publications.

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