Anti-LXR beta/NER 抗体 (ab106473)
Key features and details
- Rabbit polyclonal to LXR beta/NER
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-LXR beta/NER antibody
LXR beta/NER 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to LXR beta/NER -
由来種
Rabbit -
特異性
ab106473 is predicted not to cross-react with LXR alpha. -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Human -
免疫原
Synthetic peptide corresponding to Human LXR beta/NER (N terminal).
Database link: P55055 -
ポジティブ・コントロール
- Human lung tissue lysate
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
バッファー
pH: 7.2
Preservative: 0.02% Sodium azide
Constituent: PBS -
Concentration information loading...
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精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab106473の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
---|---|---|
WB | (1) |
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 51 kDa.
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特記事項 |
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WB
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 51 kDa. |
ターゲット情報
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機能
Orphan receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8. -
組織特異性
Ubiquitous. -
配列類似性
Belongs to the nuclear hormone receptor family. NR1 subfamily.
Contains 1 nuclear receptor DNA-binding domain. -
細胞内局在
Nucleus. - Information by UniProt
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参照データベース
- Entrez Gene: 7376 Human
- Omim: 600380 Human
- SwissProt: P55055 Human
- Unigene: 432976 Human
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別名
- Liver X nuclear receptor beta antibody
- Liver X receptor beta antibody
- LX receptor beta antibody
see all
画像
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (3)
ab106473 は 3 報の論文で使用されています。
- Courtaut F et al. Liver X receptor ligand cytotoxicity in colon cancer cells and not in normal colon epithelial cells depends on LXRß subcellular localization. Oncotarget 6:26651-62 (2015). IF . PubMed: 26450852
- Gabitova L et al. Endogenous Sterol Metabolites Regulate Growth of EGFR/KRAS-Dependent Tumors via LXR. Cell Rep 12:1927-38 (2015). PubMed: 26344763
- Derangère V et al. Liver X receptor ß activation induces pyroptosis of human and murine colon cancer cells. Cell Death Differ N/A:N/A (2014). PubMed: 25124554