Anti-LPA-3 抗体 (ab23692)
Key features and details
- Rabbit polyclonal to LPA-3
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-LPA-3 antibody
LPA-3 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to LPA-3 -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Human
交差が予測される動物種: Rat
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免疫原
Synthetic peptide corresponding to Mouse LPA-3 aa 1-12 (N terminal).
Sequence:MNECHYDKRMDF
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ポジティブ･コントロール
- WB: HepG2 cell lysate.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
バッファー
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: Tris buffered saline, 50% Glycerol, 0.1% BSA -
Concentration information loading... -
精製度
Protein A purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab23692の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB |
1/200. Detects a band of approximately 40 kDa (predicted molecular weight: 40 kDa).
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| 特記事項 |
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WB
1/200. Detects a band of approximately 40 kDa (predicted molecular weight: 40 kDa). |
ターゲット情報
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機能
Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. May play a role in the development of ovarian cancer. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins. -
組織特異性
Most abundantly expressed in prostate, testes, pancreas, and heart, with moderate levels in lung and ovary. No detectable expression in brain, placenta, liver, skeletal muscle, kidney, spleen, thymus, small intestine, colon, or peripheral blood leukocytes. -
配列類似性
Belongs to the G-protein coupled receptor 1 family. -
細胞内局在
Cell membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 23566 Human
- Entrez Gene: 66025 Rat
- Omim: 605106 Human
- SwissProt: Q9UBY5 Human
- SwissProt: Q8K5E0 Rat
- Unigene: 674915 Human
- Unigene: 64507 Rat
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別名
- Calcium mobilizing lysophosphatidic acid receptor LP A3 antibody
- Calcium mobilizing lysophosphatidic acid receptor LPA 3 antibody
- Calcium mobilizing lysophosphatidic acid receptor LPA3 antibody
see all
画像
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Western blot - Anti-LPA-3 antibody (ab23692)Anti-LPA-3 antibody (ab23692) at 2.5 µg/ml + HepG2 cell lysate (30 µg).
Predicted band size: 40 kDa
Observed band size: 40 kDa
プロトコール
データシートおよび資料
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Datasheet download
参考文献 (9)
ab23692 は 9 報の論文で使用されています。
- Chiang JC et al. Lysophosphatidic acid receptors 2 and 3 regulate erythropoiesis at different hematopoietic stages. Biochim Biophys Acta Mol Cell Biol Lipids 1866:158818 (2021). PubMed: 33035680
- Wei M et al. Downregulated circular RNA zRANB1 mediates Wnt5a/ß-Catenin signaling to promote neuropathic pain via miR-24-3p/LPAR3 axis in CCI rat models. Gene 761:145038 (2020). PubMed: 32777532
- Li GC et al. Upregulated microRNA-15b alleviates ovarian cancer through inhitbition of the PI3K/Akt pathway by targeting LPAR3. J Cell Physiol 234:22331-22342 (2019). PubMed: 31140597
- Ye Q et al. Maternal short and medium chain fatty acids supply during early pregnancy improves embryo survival through enhancing progesterone synthesis in rats. J Nutr Biochem 69:98-107 (2019). PubMed: 31063920
- Chabowski DS et al. Lysophosphatidic acid acts on LPA1 receptor to increase H2 O2 during flow-induced dilation in human adipose arterioles. Br J Pharmacol 175:4266-4280 (2018). PubMed: 30153326
- Zhang MZ et al. Lysophosphatidic Acid Receptor Antagonism Protects against Diabetic Nephropathy in a Type 2 Diabetic Model. J Am Soc Nephrol 28:3300-3311 (2017). PubMed: 28739650
- Knowlden SA et al. Regulation of T cell motility in vitro and in vivo by LPA and LPA2. PLoS One 9:e101655 (2014). WB ; Mouse . PubMed: 25003200
- Guo H et al. Cyclic regulation of LPA3 in human endometrium. Arch Gynecol Obstet 287:131-8 (2013). PubMed: 22872026
- Liszewska E et al. Lysophosphatidic acid signaling during embryo development in sheep: involvement in prostaglandin synthesis. Endocrinology : (2008). WB, IHC-Fr ; Sheep . PubMed: 18772233
