製品の概要

  • 製品名

    LP-12 hydrochloride, 5-HT7 agonist
  • 製品の詳細

    5-HT7 agonist
  • 生理活性の詳細

    5-HT7 agonist. Selective over D2, 5-HT1A and 5-HT2A receptors (Ki values are 0.13, 224, 60.9 and >1000 nM, respectively). Shows pro-nociceptive effect.
  • 精製度

    > 98%
  • CAS 番号

    1185136-22-4
  • 構造式

    Chemical Structure

製品の特性

参考文献

This product has been referenced in:

  • Leopoldo M  et al. Serotonin 5-HT7 receptor agents: Structure-activity relationships and potential therapeutic applications in central nervous system disorders. Pharmacol Ther 129:120-48 (2011). Read more (PubMed: 20923682) »
  • Godínez-Chaparro B  et al. Role of peripheral 5-HT(4), 5-HT(6), and 5-HT(7) receptors in development and maintenance of secondary mechanical allodynia and hyperalgesia. Pain 152:687-97 (2011). Read more (PubMed: 21239110) »
  • Leopoldo M  et al. Structure-activity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides, a class of 5-HT7 receptor agents. 2. J Med Chem 50:4214-21 (2007). Read more (PubMed: 17649988) »
  • Stern CD  et al. Segmental lineage restrictions in the chick embryo spinal cord depend on the adjacent somites. Development 113:239-44 (1991). Read more (PubMed: 1764998) »

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