Lovastatin (Mevinolin), HMG-CoA reductase inhibitor (ab120614)
Key features and details
- Potent HMG-CoA reductase inhibitor
- CAS Number: 75330-75-5
- Soluble in DMSO to 100 mM and in ethanol to 50 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
Lovastatin (Mevinolin), HMG-CoA reductase inhibitor -
製品の詳細
Potent HMG-CoA reductase inhibitor -
別名
- Mevinolin
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生理活性の詳細
Potent, competitive HMG-CoA reductase inhibitor (Ki = 0.6 nM). Blood-brain barrier permeable. Inhibits in vivo and in vitro cholesterol biosynthesis. Also reduces α-synuclein levels in vitro and in vivo.
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CAS 番号
75330-75-5 -
構造式
製品の特性
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体系名
(2S)-(1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl-2-methyl butanoate -
分子量
404.54 -
分子式
C24H36O5 -
PubChem 登録番号
53232 -
保存方法
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in DMSO to 100 mM and in ethanol to 50 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
CC[C@H](C)C(=O)O[C@H]1C[C@H](C=C2[C@H]1[C@H]([C@H](C=C2)C)CC[C@@H]3C[C@H](CC(=O)O3)O)C -
由来
Synthetic
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研究分野
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Cholesterol Metabolism
- Biochemicals
- Research Area
- Pain & inflammation
- Signaling
- Lipid signaling
- HMG-CoA reductase
- Inhibitors
- Biochemicals
- Research Area
- Alzheimer's Disease
- Signaling
- Lipid signaling
- HMG-CoA reductase
- Inhibitors
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab120614の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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Functional Studies |
Use at an assay dependent concentration.
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特記事項 |
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Functional Studies
Use at an assay dependent concentration. |
画像
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2D chemical structure image of ab120614, Lovastatin (Mevinolin), HMG-CoA reductase inhibitor
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ab87359 staining cyclin A in DU145 cells treated with lovastatin (ab120614), by ICC/IF. Decrease in cyclin A expression correlates with increased concentration of lovastatin, as described in literature.
The cells were incubated at 37°C for 24h in media containing different concentrations of ab120614 (lovastatin) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab87359 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (6)
ab120614 は 6 報の論文で使用されています。
- Farfan-Morales CN et al. The antiviral effect of metformin on zika and dengue virus infection. Sci Rep 11:8743 (2021). PubMed: 33888740
- Zheng C et al. Lovastatin Inhibits EMT and Metastasis of Triple-Negative Breast Cancer Stem Cells Through Dysregulation of Cytoskeleton-Associated Proteins. Front Oncol 11:656687 (2021). PubMed: 34150623
- Dorsch M et al. Statins affect cancer cell plasticity with distinct consequences for tumor progression and metastasis. Cell Rep 37:110056 (2021). PubMed: 34818551
- Canela A et al. Topoisomerase II-Induced Chromosome Breakage and Translocation Is Determined by Chromosome Architecture and Transcriptional Activity. Mol Cell 75:252-266.e8 (2019). PubMed: 31202577
- Peng Y et al. Lovastatin Inhibits Cancer Stem Cells and Sensitizes to Chemo- and Photodynamic Therapy in Nasopharyngeal Carcinoma. J Cancer 8:1655-1664 (2017). PubMed: 28775785
- Restivo G et al. low neurotrophin receptor CD271 regulates phenotype switching in melanoma. Nat Commun 8:1988 (2017). PubMed: 29215016