Anti-LONP1/Lon 抗体 (ab103809)
Key features and details
- Rabbit polyclonal to LONP1/Lon
- Suitable for: WB
- Reacts with: Mouse, Human
- Isotype: IgG
製品の概要
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製品名
Anti-LONP1/Lon antibody
LONP1/Lon 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to LONP1/Lon -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Mouse, Human -
免疫原
Recombinant full length protein corresponding to Human LONP1/Lon aa 1-959.
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ポジティブ・コントロール
- Human kidney, Mouse kidney, HepG2, transfected 293T cell line
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
バッファー
pH: 7.4
Constituent: PBS -
Concentration information loading...
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精製度
Protein A purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Positive Controls
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab103809の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB | (2) |
Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 106 kDa.
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特記事項 |
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WB
Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 106 kDa. |
ターゲット情報
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機能
ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand-specific manner. May regulate mitochondrial DNA replication and/or gene expression using site-specific, single-stranded DNA binding to target the degradation of regulatory proteins binding to adjacent sites in mitochondrial promoters. Endogenous substrates include mitochondrial steroidogenic acute regulatory (StAR) protein. -
組織特異性
Duodenum, heart, lung and liver, but not thymus. -
関連疾患
CODAS syndrome -
配列類似性
Belongs to the peptidase S16 family.
Contains 1 Lon domain. -
細胞内局在
Mitochondrion matrix. - Information by UniProt
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参照データベース
- Entrez Gene: 9361 Human
- Entrez Gene: 74142 Mouse
- Omim: 605490 Human
- SwissProt: P36776 Human
- SwissProt: Q8CGK3 Mouse
- Unigene: 350265 Human
- Unigene: 329136 Mouse
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別名
- hLON antibody
- hLON ATP dependent protease antibody
- LON antibody
see all
画像
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Anti-LONP1/Lon antibody (ab103809) at 5 µg/ml + Human kidney tissue lysate at 50 µg
Predicted band size: 106 kDa -
Anti-LONP1/Lon antibody (ab103809) at 5 µg/ml + Mouse kidney tissue lysate at 50 µg
Predicted band size: 106 kDa -
Anti-LONP1/Lon antibody (ab103809) at 5 µg/ml + HepG2 cell lysate at 50 µg
Predicted band size: 106 kDa -
All lanes : Anti-LONP1/Lon antibody (ab103809) at 5 µg/ml
Lane 1 : LONP1 transfected 293T cell lysate
Lane 2 : Non-transfected 293T cell lysate
Lysates/proteins at 25 µg per lane.
Predicted band size: 106 kDa
データシートおよび資料
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Datasheet download
参考文献 (24)
ab103809 は 24 報の論文で使用されています。
- Chattopadhyay M et al. The portrait of liver cancer is shaped by mitochondrial genetics. Cell Rep 38:110254 (2022). PubMed: 35045282
- Cai G et al. Rosmarinic Acid Inhibits Mitochondrial Damage by Alleviating Unfolded Protein Response. Front Pharmacol 13:859978 (2022). PubMed: 35652041
- Zanini G et al. Differential Expression of Lonp1 Isoforms in Cancer Cells. Cells 11:N/A (2022). PubMed: 36497197
- Gao X et al. ATF5, a putative therapeutic target for the mitochondrial DNA 3243A > G mutation-related disease. Cell Death Dis 12:701 (2021). PubMed: 34262025
- Lee Y et al. General anesthesia activates the mitochondrial unfolded protein response and induces age-dependent, long-lasting changes in mitochondrial function in the developing brain. Neurotoxicology 82:1-8 (2021). PubMed: 33144179