製品の概要

  • 製品名

    L-745870 trihydrochloride, brain penetrant D4 antagonist
  • 製品の詳細

    Highly potent, selective brain penetrant D4 antagonist
  • 生理活性の詳細

    Highly potent and selective D4 antagonist (Ki values are 0.43, 2300 and 960 nM at D4, D3 and D2, respectively). Brain permeable. Inhibits cell death and shows neuroprotective effects.
  • 精製度

    > 99%
  • CAS 番号

    866021-03-6
  • 構造式

    Chemical Structure

製品の特性

参考文献

This product has been referenced in:

  • Tanaka K  et al. A dopamine receptor antagonist L-745,870 suppresses microglia activation in spinal cord and mitigates the progression in ALS model mice. Exp Neurol 211:378-86 (2008). Read more (PubMed: 18423451) »
  • Mamiya T  et al. Effects of L-745,870, a dopamine D4 receptor antagonist, on naloxone-induced morphine dependence in mice. Ann N Y Acad Sci 1025:424-9 (2004). Read more (PubMed: 15542745) »
  • Patel S  et al. Biological profile of L-745,870, a selective antagonist with high affinity for the dopamine D4 receptor. J Pharmacol Exp Ther 283:636-47 (1997). Read more (PubMed: 9353380) »

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