Anti-Kv4.2/KCND2 抗体 (ab16719)
Key features and details
- Rabbit polyclonal to Kv4.2/KCND2
- Suitable for: ELISA, IP, ICC/IF, WB
- Reacts with: Rat
- Isotype: IgG
製品の概要
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製品名
Anti-Kv4.2/KCND2 antibody
Kv4.2/KCND2 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to Kv4.2/KCND2 -
由来種
Rabbit -
アプリケーション
適用あり: ELISA, IP, ICC/IF, WBmore details -
種交差性
交差種: Rat
交差が予測される動物種: Mouse, Rabbit, Human, Ferret
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免疫原
Synthetic peptide corresponding to Rat Kv4.2/KCND2 aa 453-470 conjugated to keyhole limpet haemocyanin.
Database link: Q63881 -
特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
バッファー
pH: 7.40
Preservative: 0.08% Sodium azide
Constituent: PBS -
Concentration information loading... -
精製度
Ammonium Sulphate Precipitation -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab16719の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| ELISA | (1) |
Use at an assay dependent concentration.
|
| IP |
Use at an assay dependent concentration.
|
|
| ICC/IF |
Use at an assay dependent concentration.
|
|
| IF |
Use at an assay dependent concentration.
|
|
| WB | (1) |
Use at an assay dependent concentration.
|
| 特記事項 |
|---|
|
ELISA
Use at an assay dependent concentration. |
|
IP
Use at an assay dependent concentration. |
|
ICC/IF
Use at an assay dependent concentration. |
|
IF
Use at an assay dependent concentration. |
|
WB
Use at an assay dependent concentration. |
ターゲット情報
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機能
Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits. -
組織特異性
Highly expressed throughout the brain. Expression is very low or absent in other tissues. -
配列類似性
Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.2/KCND2 sub-subfamily. -
ドメイン
The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. -
翻訳後修飾
Phosphorylated on serine and threonine residues. -
細胞内局在
Cell membrane. Cell projection > dendrite. Detected in dendrites in cultured hippocampal neurons. Association with KCNIP2 probably enhances cell surface expression. - Information by UniProt
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参照データベース
- Entrez Gene: 3751 Human
- Entrez Gene: 16508 Mouse
- Entrez Gene: 100008841 Rabbit
- Entrez Gene: 65180 Rat
- Omim: 605410 Human
- SwissProt: Q9NZV8 Human
- SwissProt: Q9Z0V2 Mouse
- SwissProt: P59995 Rabbit
see all -
別名
- KCD2 antibody
- KCND 2 antibody
- KCND2 antibody
see all
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (4)
ab16719 は 4 報の論文で使用されています。
- Yao J et al. Limiting RyR2 Open Time Prevents Alzheimer's Disease-Related Neuronal Hyperactivity and Memory Loss but Not ß-Amyloid Accumulation. Cell Rep 32:108169 (2020). PubMed: 32966798
- Yang CH et al. A critical role for protein tyrosine phosphatase nonreceptor type 5 in determining individual susceptibility to develop stress-related cognitive and morphological changes. J Neurosci 32:7550-62 (2012). PubMed: 22649233
- Noam Y et al. Trafficking and surface expression of hyperpolarization-activated cyclic nucleotide-gated channels in hippocampal neurons. J Biol Chem 285:14724-36 (2010). WB ; Rat . PubMed: 20215108
- Stones R et al. The role of transient outward K+ current in electrical remodelling induced by voluntary exercise in female rat hearts. Basic Res Cardiol 104:643-52 (2009). WB ; Rat . PubMed: 19415411