製品の概要

  • 製品名

    KU 0063794, mTOR inhibitor
  • 製品の詳細

    Potent and selective mTOR inhibitor
  • 生理活性の詳細

    Potent mTOR inhibitor (mTORC1 & mTOTC2 IC50 = 10 nM). Highly selective against a panel of 76 protein kinases and 7 lipid kinases. Inhibits activation of Akt, S6K and SGK. Suppresses cell growth and induces G1 cell cycle arrest in vitro

  • 精製度

    > 98%
  • 特記事項

    Protect from air and light.

  • CAS 番号

    938440-64-3
  • 構造式

    Chemical Structure

製品の特性

  • 体系名

    rel-5-[2-[(2R,6S)-2,6-Dimethyl-4-morpholinyl]-4-(4-morpholinyl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxybenzenemethanol
  • 分子量

    465.55
  • 分子式

    C25H31N5O4
  • PubChem 登録番号

    16736978
  • 保存方法

    Shipped at 4°C. Store at -20°C long term. Store In the Dark.
  • 溶解性

    Soluble in DMSO to 10 mM
  • 使用に関する注意

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Toxic, refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES 線形表記

    C[C@@H]1CN(C[C@@H](O1)C)C2=NC3=C(C=CC(=N3)C4=CC(=C(C=C4)OC)CO)C(=N2)N5CCOCC5
  • 由来

    Synthetic

参考文献

This product has been referenced in:

  • Yongxi T  et al. Autophagy inhibition sensitizes KU-0063794-mediated anti-HepG2 hepatocellular carcinoma cell activity in vitro and in vivo. Biochem Biophys Res Commun 465:494-500 (2015). Read more (PubMed: 26278819) »
See all 2 Publications for this product

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