Anti-KCNV2 抗体 (ab214587)
Key features and details
- Rabbit polyclonal to KCNV2
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-KCNV2 antibody -
製品の詳細
Rabbit polyclonal to KCNV2 -
由来種
Rabbit -
アプリケーション
適用あり: IHC-Pmore details -
種交差性
交差種: Human
交差が予測される動物種: Mouse, Rat -
免疫原
Synthetic peptide within Human KCNV2 aa 150-250 conjugated to keyhole limpet haemocyanin. The exact immunogen sequence used to generate this antibody is proprietary information. If additional detail on the immunogen is needed to determine the suitability of the antibody for your needs, please contact our Scientific Support team to discuss your requirements.
Database link: Q8TDN2 -
ポジティブ・コントロール
- Human colon carcinoma tissue.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
バッファー
pH: 7.40
Preservative: 0.02% Proclin 300
Constituents: 50% Glycerol (glycerin, glycerine), 1% BSA, 48.98% TBS, 1X -
Concentration information loading...
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精製度
Protein A purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab214587の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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IHC-P |
1/100 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
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特記事項 |
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IHC-P
1/100 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
ターゲット情報
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機能
Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values. -
組織特異性
Detected in lung, liver, kidney, pancreas, spleen, thymus, prostate, testis, ovary and colon. -
関連疾患
Defects in KCNV2 are the cause of cone dystrophy retinal type 3B (RCD3B) [MIM:610356]; also called cone dystrophy with night blindness and supernormal rod responses KCNV2-related. RCD3B is a rare form of cone dystrophy associated with supernormal rod responses. The disorder is characterized by reduced visual acuity, photoaversion, night blindness, and abnormal color vision. At an early age, the retina shows subtle depigmentation at the macula and, later, more obvious areas of atrophy. -
配列類似性
Belongs to the potassium channel family. V (TC 1.A.1.2) subfamily. Kv8.2/KCNV2 sub-subfamily. -
ドメイン
The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. -
細胞内局在
Cell membrane. Has to be associated with KCNB1 or possibly another partner to get inserted in the plasma membrane. Remains intracellular in the absence of KCNB1. - Information by UniProt
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参照データベース
- Entrez Gene: 169522 Human
- Entrez Gene: 240595 Mouse
- Entrez Gene: 294065 Rat
- Omim: 607604 Human
- SwissProt: Q8TDN2 Human
- SwissProt: Q8CFS6 Mouse
- Unigene: 624689 Human
- Unigene: 660831 Human
see all -
別名
- KCNV2 antibody
- KCNV2_HUMAN antibody
- KV11.1 antibody
see all
画像
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Immunohistochemical analysis of paraformaldehyde-fixed, paraffin-embedded human colon carcinoma tissue labeling KCNV2 with ab214587 at 1/400 dilution, followed by secondary antibody detection and DAB staining.
Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min.
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (0)
ab214587 は論文での使用が確認できていません。