Anti-KCNQ5 抗体 (ab96707)
Key features and details
- Rabbit polyclonal to KCNQ5
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
製品の概要
-
製品名
Anti-KCNQ5 antibody
KCNQ5 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to KCNQ5 -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Human
交差が予測される動物種: Mouse -
免疫原
Recombinant protein fragment containing a sequence corresponding to a region within amino acids 458 and 684 of Human KCNQ5
-
特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
-
製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
バッファー
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 1.21% Tris, 0.75% Glycine, 10% Glycerol (glycerin, glycerine) -
Concentration information loading...
-
精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
-
Compatible Secondaries
-
Isotype control
-
Positive Controls
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab96707の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
---|---|---|
WB |
1/500 - 1/3000. Predicted molecular weight: 102 kDa.
|
特記事項 |
---|
WB
1/500 - 1/3000. Predicted molecular weight: 102 kDa. |
ターゲット情報
-
機能
Probably important in the regulation of neuronal excitability. Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. May contribute, with other potassium channels, to the molecular diversity of an heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current. Insensitive to tetraethylammonium, but inhibited by barium, linopirdine and XE991. Activated by niflumic acid and the anticonvulsant retigabine. Muscarine suppresses KCNQ5 current in Xenopus oocytes in which cloned KCNQ5 channels were coexpressed with M(1) muscarinic receptors. -
組織特異性
Strongly expressed in brain and skeletal muscle. In brain, expressed in cerebral cortex, occipital pole, frontal lobe and temporal lobe. Lower levels in hippocampus and putamen. Low to undetectable levels in medulla, cerebellum and thalamus. -
配列類似性
Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.5/KCNQ5 sub-subfamily. -
ドメイン
The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. -
細胞内局在
Membrane. - Information by UniProt
-
参照データベース
- Entrez Gene: 56479 Human
- Entrez Gene: 226922 Mouse
- Omim: 607357 Human
- SwissProt: Q9NR82 Human
- SwissProt: Q9JK45 Mouse
- Unigene: 445324 Human
- Unigene: 336519 Mouse
- Unigene: 403737 Mouse
-
別名
- KCNQ 5 antibody
- KCNQ5 antibody
- KCNQ5_HUMAN antibody
see all
画像
プロトコール
データシートおよび資料
-
SDS download
-
Datasheet download
参考文献 (1)
ab96707 は 1 報の論文で使用されています。
- Brueggemann LI et al. Differential protein kinase C-dependent modulation of Kv7.4 and Kv7.5 subunits of vascular Kv7 channels. J Biol Chem 289:2099-111 (2014). ICC/IF . PubMed: 24297175