KB-R7943, NCX inhibitor (ab120284)
Key features and details
- NCX inhibitor. TRPC blocker.
- CAS Number: 182004-65-5
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
KB-R7943, NCX inhibitor -
製品の詳細
NCX inhibitor. TRPC blocker. -
生理活性の詳細
Potent, selective inhibitor of the reverse mode of the Na+/Ca2+ exchanger (IC50 = ~0.32 μM in guinea pig ventricular cells). Also potent blocker of TRPC channels (IC50 values are 0.46, 0.71 and 1.38 μM at TRPC3, TRPC6 and TRPC5, respectively).
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CAS 番号
182004-65-5 -
構造式
製品の特性
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体系名
2-[4-[(4-nitrophenyl)methoxy]phenyl]ethyl ester carbamimidothioic acid methanesulfonate -
分子量
427.49 -
分子式
C16H17N3O3S.CH3SO3H -
PubChem 登録番号
9823846 -
保存方法
Store at Room Temperature. The product can be stored for up to 12 months. -
溶解性
Soluble in DMSO to 100 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
CS(=O)(=O)O.[O-][N+](=O)c2ccc(COc1ccc(cc1)CCSC(=N)N)cc2 -
由来
Synthetic
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研究分野
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (4)
ab120284 は 4 報の論文で使用されています。
- Wong RW et al. An activator of G protein-coupled receptor and MEK1/2-ERK1/2 signaling inhibits HIV-1 replication by altering viral RNA processing. PLoS Pathog 16:e1008307 (2020). PubMed: 32069328
- Wong RW et al. Cardiac glycoside/aglycones inhibit HIV-1 gene expression by a mechanism requiring MEK1/2-ERK1/2 signaling. Sci Rep 8:850 (2018). PubMed: 29339801
- Di Giuro CML et al. Na +/Ca2+ exchangers and Orai channels jointly refill endoplasmic reticulum (ER) Ca2+ via ER nanojunctions in vascular endothelial cells. Pflugers Arch 469:1287-1299 (2017). PubMed: 28497275
- Sherkhane P & Kapfhammer JP Chronic pharmacological blockade of the Na(+) /Ca(2+) exchanger modulates the growth and development of the Purkinje cell dendritic arbor in mouse cerebellar slice cultures. Eur J Neurosci N/A:N/A (2017). PubMed: 28715135