KAT13D / CLOCK peptide (ab5854)

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Key features and details

  • Purity: > 95% SDS-PAGE
  • Suitable for: Blocking

製品の詳細

関連製品

特性

Our Abpromise guarantee covers the use of ab5854 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking

  • 製品の状態

    Lyophilized

  • 備考


    This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and mouse CLOCK, catalog ab3517. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (70-fold) for competitive inhibition of antibody-protein binding reactions.

  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

  • 再構成
    Reconstitute with 0.1 mL of distilled water.

関連情報

  • 別名

    • bHLHe8
    • Circadian locomoter output cycles kaput protein
    • Circadian locomoter output cycles protein kaput
    • Circadian Locomotor Output Cycles Kaput
    • Circadium Locomotor Output Cycles Kaput
    • Class E basic helix-loop-helix protein 8
    • CLOCK
    • Clock circadian regulator
    • Clock homolog
    • Clock protein
    • CLOCK_HUMAN
    • hCLOCK
    • KIAA0334
    see all

  • 機能

    ARNTL/2-CLOCK heterodimers activate E-box element (3'-CACGTG-5') transcription of a number of proteins of the circadian clock. Activates transcription of PER1 and PER2. This transcription is inhibited in a feedback loop by PER and CRY proteins. Has intrinsic histone acetyltransferase activity and this enzymatic function contributes to chromatin-remodeling events implicated in circadian control of gene expression (By similarity). Acetylates primarily histones H3 and H4 (By similarity). Acetylates also a non-histone substrate: ARNTL.

  • 組織特異性

    Expressed in all tissues examined including spleen, thymus, prostate, testis, ovary, small intestine, colon, leukocytes, heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highest levels in testis and skeletal muscle. Low levels in thymus, lung and liver. Expressed in all brain regions with highest levels in cerebellum. Highly expressed in the suprachiasmatic nucleus (SCN).

  • 配列類似性

    Contains 1 basic helix-loop-helix (bHLH) domain.
    Contains 1 PAC (PAS-associated C-terminal) domain.
    Contains 2 PAS (PER-ARNT-SIM) domains.

  • 翻訳後修飾

    Phosphorylation is dependent on CLOCK-ARNTL heterodimer formation.

  • 細胞内局在

    Cytoplasm. Nucleus. Shuffling between the cytoplasm and the nucleus is under circadian regulation and is ARNTL-dependent. Phosphorylated form located in the nucleus.
  • Information by UniProt

プロトコール

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

参考文献 (0)

ab5854 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

ab5854 は論文での使用が確認できていません。

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