Anti-Kallikrein 5 抗体 (ab7283)

Submit a review Q&A (3)References (4)

Key features and details

  • Rabbit polyclonal to Kallikrein 5
  • Isotype: IgG

製品の概要

  • 製品名

    Anti-Kallikrein 5 antibody
    Kallikrein 5 一次抗体 製品一覧

  • 製品の詳細

    Rabbit polyclonal to Kallikrein 5

  • 由来種

    Rabbit

  • 免疫原

    Synthetic peptide, corresponding to amino acids 280-293 of Human KLK5.

  • 特記事項

    Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

    Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

    We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

    In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

    We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

    Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

    Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

製品の特性

ターゲット情報

  • 機能

    May be involved in desquamation.

  • 組織特異性

    Expressed in skin, breast, brain and testis. Expressed at the stratum granulosum of palmar skin.

  • 配列類似性

    Belongs to the peptidase S1 family. Kallikrein subfamily.
    Contains 1 peptidase S1 domain.

  • 細胞内局在

    Secreted.
  • Information by UniProt

  • 別名

    • HK5 antibody
    • Kallikrein 5 antibody
    • Kallikrein L2 antibody
    • Kallikrein like 2 antibody
    • Kallikrein like protein 2 antibody
    • Kallikrein related peptidase 5 antibody
    • Kallikrein-5 antibody
    • Kallikrein-like protein 2 antibody
    • Kallikrein5 antibody
    • KLK 5 antibody
    • KLK L2 antibody
    • KLK-L2 antibody
    • KLK5 antibody
    • KLK5_HUMAN antibody
    • KLKL 2 antibody
    • KLKL2 antibody
    • SCTE antibody
    • Stratum corneum tryptic enzyme antibody
    • UNQ570/PRO1132 antibody
    see all

参考文献 (4)

ab7283 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

ab7283 は 4 報の論文で使用されています。

  • Furio L  et al. Transgenic kallikrein 5 mice reproduce major cutaneous and systemic hallmarks of Netherton syndrome. J Exp Med 211:499-513 (2014). PubMed: 24534191
  • Bonnart C  et al. Elastase 2 is expressed in human and mouse epidermis and impairs skin barrier function in Netherton syndrome through filaggrin and lipid misprocessing. J Clin Invest 120:871-82 (2010). IHC-P ; Human . PubMed: 20179351
  • Yanagi T  et al. Self-improvement of keratinocyte differentiation defects during skin maturation in ABCA12-deficient harlequin ichthyosis model mice. Am J Pathol 177:106-18 (2010). WB, IHC-P ; Mouse . PubMed: 20489143
  • Di WL  et al. A heterozygous null mutation combined with the G1258A polymorphism of SPINK5 causes impaired LEKTI function and abnormal expression of skin barrier proteins. Br J Dermatol 161:404-12 (2009). WB ; Human . PubMed: 19438860

レビューと Q&A

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1-3 of 3 Abreviews or Q&A

Question

Je souhaite commander les références ab7283 et ab96710 mais je souhaiterai savoir si ces 2 anticorps reconnaitront la forme active de la kallikrein5 et kallikrein7.

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Answer

L’immunogène d’ab7283 correspond aux acides amines 280-293 de la protéine kallikrein 5 humaine. Ces acides aminés sont présents chez la forme active de la protéine.

L’immunogène d’ab96710 se trouve dans les acides aminés 30-253 de la protéine kallikrein 7 qui est la forme active de la protéine.

Je peux donc vous confirmer que ces deux anticorps reconnaissent à la fois les formes actives et non actives de ces protéines.

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Question

Hi is it possible for you to email me copies of the relevant msds for the following antibodies please?
Ab7283

Ab80790

Ab63982

Ab64892

Ab24722

Ab64409

Ab45091

Kind regards
.

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Answer

Thank you for contacting us.
Please find attached the Material Safety Datasheet for some of the products requested. Those products not containing any hazardous products do not require MSDS.
If by any chance you required these datasheets for legal requirements, please do not hesitate to let me know, as we can still prepare it for you.

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Question

In the datasheet one can find the applicaton note, that it works in western blot. Does this mean under native or under denaturing conditions? Also the Abreview from Douglas Taylor about western blot with this ab doesn´t tell, if it was made under native or denatured conditions. I´m asking, because we are searching now since quite a space of time for an ab against KLK5, which functions in paraffin-embedded tissue sections. Thanks a lot for your assistance and patience.

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Answer

Thank you for your enquiry. The antibody ab7283 has been tested in standard reducing conditions in western blotting and has not been tested in IHC-P. It may work in IHC-P and should you decide to go ahead and purchase this product, please let us know how you get on by submitting an Abreview and in return we will offer you 50 Abpoints which can be redeemed on a number of rewards (a further 100 Abpoints will be offered for an image).

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