Anti-ITPR2 抗体 (ab5805)

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Immunocytochemistry - Anti-ITPR2 antibody (ab5805)
  • Immunohistochemistry (Frozen sections) - Anti-ITPR2 antibody (ab5805)

Key features and details

  • Rabbit polyclonal to ITPR2
  • Suitable for: ICC, IHC-Fr
  • Reacts with: Rat
  • Isotype: IgG

製品の概要

  • 製品名

    Anti-ITPR2 antibody
    ITPR2 一次抗体 製品一覧

  • 製品の詳細

    Rabbit polyclonal to ITPR2

  • 由来種

    Rabbit

  • アプリケーション

    適用あり: ICC, IHC-Frmore details
    適用なし: WB

  • 種交差性

    交差種: Rat
    交差が予測される動物種: Cow

  • 免疫原

    Synthetic peptide corresponding to Rat ITPR2 aa 317-334.
    Sequence:

    ELNPDYRDAQNEGKTVRD


    (Peptide available as ab5842)
    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI

  • ポジティブ･コントロール

    • IHC-Fr: Rat brasin tissue. ICC: SH-SY5Y cells.

  • 特記事項

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

    If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

製品の特性

アプリケーション

The Abpromise guarantee

Abpromise保証は、 次のテスト済みアプリケーションにおけるab5805の使用に適用されます

アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。

アプリケーション Abreviews 特記事項
ICC
Use a concentration of 2 µg/ml.
IHC-Fr
1/100.
特記事項
ICC
Use a concentration of 2 µg/ml.
IHC-Fr
1/100.
追加情報
Is unsuitable for WB.

ターゲット情報

  • 機能

    Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA.

  • 組織特異性

    Isoform Short is found in skeletal muscle and heart.

  • 関連疾患

    Anhidrosis, isolated, with normal sweat glands

  • 配列類似性

    Belongs to the InsP3 receptor family.
    Contains 5 MIR domains.

  • ドメイン

    The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.

  • 翻訳後修飾

    Phosphorylation by cAMP-dependent PKA on Ser-937 increases calcium release.

  • 細胞内局在

    Endoplasmic reticulum membrane.
  • Information by UniProt

  • 参照データベース

    • 別名

      • 4 antibody
      • 5-trisphosphate receptor antibody
      • Inositol 1 4 5 trisphosphate receptor type 2 antibody
      • Inositol 1,4,5-trisphosphate receptor type 2 antibody
      • Inositol 145 trisphosphate receptor type 2 antibody
      • InsP3 R2 antibody
      • InsP3R2 antibody
      • IP3 R2 antibody
      • IP3 receptor antibody
      • IP3 receptor isoform 2 antibody
      • IP3R 2 antibody
      • IP3R2 antibody
      • ITPR 2 antibody
      • Itpr2 antibody
      • ITPR2_HUMAN antibody
      • Type 2 inositol 1 4 5 trisphosphate receptor antibody
      • Type 2 inositol 1 antibody
      • Type 2 inositol 145 trisphosphate receptor antibody
      • Type 2 InsP3 receptor antibody
      see all

    画像

    • Immunocytochemistry - Anti-ITPR2 antibody (ab5805)
      Immunocytochemistry - Anti-ITPR2 antibody (ab5805)

      4% paraformaldehyde-fixed, 0.1% Triton X-100 permeabilised SH-SY5Y (human neuroblastoma cell line from bone marrow) cells labeling ITPR2 using ab5805 at 2 μg/ml in 0.1% BSAfor 3 hours at RT, followed by a Goat Anti-Rabbit (H&L) AlexaFluor® secondary antibody (Green (a)). The nuclear counter stain is DAPI (Blue (b)). F-actin is stained with AlexaFluor® 555-Rhodamine (Red (c)). Panel D shows the merged image. Panel (e) is a secondary antibody only control.

    • Immunohistochemistry (Frozen sections) - Anti-ITPR2 antibody (ab5805)
      Immunohistochemistry (Frozen sections) - Anti-ITPR2 antibody (ab5805)
      Shows immunolocalization of IP3R-II in rat brain using ab5805.

    参考文献 (3)

    ab5805 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

    ab5805 は 3 報の論文で使用されています。

    • Jaiswal PK  et al. Biochemical characteristics of the chondrocyte-enriched SNORC protein and its transcriptional regulation by SOX9. Sci Rep 10:7790 (2020). PubMed: 32385306
    • Causton B  et al. CARMA3 Mediates Allergic Lung Inflammation in Response to Alternaria alternata. Am J Respir Cell Mol Biol 59:684-694 (2018). PubMed: 29958012
    • Okamoto Y  et al. Arrhythmogenic coupling between the Na+ -Ca2+ exchanger and inositol 1,4,5-triphosphate receptor in rat pulmonary vein cardiomyocytes. J Mol Cell Cardiol 52:988-97 (2012). ICC/IF ; Rat . PubMed: 22285480

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