Anti-ITPR2 抗体 (ab5805)

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Key features and details

  • Rabbit polyclonal to ITPR2
  • Suitable for: IHC-Fr
  • Reacts with: Mouse, Rat, Human, Amphibian, Salamander
  • Isotype: IgG

製品の概要

  • 製品名

    Anti-ITPR2 antibody
    ITPR2 一次抗体 製品一覧

  • 製品の詳細

    Rabbit polyclonal to ITPR2

  • 由来種

    Rabbit

  • アプリケーション

    適用あり: IHC-Frmore details
    適用なし: WB

  • 種交差性

    交差種: Mouse, Rat, Human, Amphibian, Salamander
    交差が予測される動物種: Cow

  • 免疫原

    Synthetic peptide corresponding to Rat ITPR2 aa 317-334.
    Sequence:

    ELNPDYRDAQNEGKTVRD


    (Peptide available as ab5842)

    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab5805 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-Fr 1/100.
  • 追加情報
    Is unsuitable for WB.

    • ターゲット情報

    • 機能

      Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA.

    • 組織特異性

      Isoform Short is found in skeletal muscle and heart.

    • 関連疾患

      Anhidrosis, isolated, with normal sweat glands

    • 配列類似性

      Belongs to the InsP3 receptor family.
      Contains 5 MIR domains.

    • ドメイン

      The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.

    • 翻訳後修飾

      Phosphorylation by cAMP-dependent PKA on Ser-937 increases calcium release.

    • 細胞内局在

      Endoplasmic reticulum membrane.
    • Information by UniProt

    • 参照データベース

      see all

    • 別名

      • 4 antibody
      • 5-trisphosphate receptor antibody
      • Inositol 1 4 5 trisphosphate receptor type 2 antibody
      • Inositol 1,4,5-trisphosphate receptor type 2 antibody
      • Inositol 145 trisphosphate receptor type 2 antibody
      • InsP3 R2 antibody
      • InsP3R2 antibody
      • IP3 R2 antibody
      • IP3 receptor antibody
      • IP3 receptor isoform 2 antibody
      • IP3R 2 antibody
      • IP3R2 antibody
      • ITPR 2 antibody
      • Itpr2 antibody
      • ITPR2_HUMAN antibody
      • Type 2 inositol 1 4 5 trisphosphate receptor antibody
      • Type 2 inositol 1 antibody
      • Type 2 inositol 145 trisphosphate receptor antibody
      • Type 2 InsP3 receptor antibody
      see all

    画像

    • Immunohistochemistry (Frozen sections) - Anti-ITPR2 antibody (ab5805)
      Immunohistochemistry (Frozen sections) - Anti-ITPR2 antibody (ab5805)
      Shows immunolocalization of IP3R-II in rat brain using ab5805.

    参考文献 (2)

    ab5805 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

    ab5805 は 2 報の論文で使用されています。

    • Causton B  et al. CARMA3 Mediates Allergic Lung Inflammation in Response to Alternaria alternata. Am J Respir Cell Mol Biol 59:684-694 (2018). PubMed: 29958012
    • Okamoto Y  et al. Arrhythmogenic coupling between the Na+ -Ca2+ exchanger and inositol 1,4,5-triphosphate receptor in rat pulmonary vein cardiomyocytes. J Mol Cell Cardiol 52:988-97 (2012). ICC/IF ; Rat . PubMed: 22285480

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