Anti-ITPR2 抗体 (ab5805)

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Key features and details

  • Rabbit polyclonal to ITPR2
  • Suitable for: IHC-Fr
  • Reacts with: Mouse, Rat, Human, Amphibian, Salamander
  • Isotype: IgG

製品の概要

  • 製品名

    Anti-ITPR2 antibody
    ITPR2 一次抗体 製品一覧

  • 製品の詳細

    Rabbit polyclonal to ITPR2

  • 由来種

    Rabbit

  • アプリケーション

    適用あり: IHC-Frmore details
    適用なし: WB

  • 種交差性

    交差種: Mouse, Rat, Human, Amphibian, Salamander
    交差が予測される動物種: Cow

  • 免疫原

    Synthetic peptide corresponding to Rat ITPR2 aa 317-334.
    Sequence:

    ELNPDYRDAQNEGKTVRD


    (Peptide available as ab5842)

    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI

  • 特記事項

    Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

    Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

    We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

    In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

    We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

    Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

    Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab5805 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-Fr 1/100.
  • 追加情報
    Is unsuitable for WB.

    • ターゲット情報

    • 機能

      Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA.

    • 組織特異性

      Isoform Short is found in skeletal muscle and heart.

    • 関連疾患

      Anhidrosis, isolated, with normal sweat glands

    • 配列類似性

      Belongs to the InsP3 receptor family.
      Contains 5 MIR domains.

    • ドメイン

      The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.

    • 翻訳後修飾

      Phosphorylation by cAMP-dependent PKA on Ser-937 increases calcium release.

    • 細胞内局在

      Endoplasmic reticulum membrane.
    • Information by UniProt

    • 参照データベース

      see all

    • 別名

      • 4 antibody
      • 5-trisphosphate receptor antibody
      • Inositol 1 4 5 trisphosphate receptor type 2 antibody
      • Inositol 1,4,5-trisphosphate receptor type 2 antibody
      • Inositol 145 trisphosphate receptor type 2 antibody
      • InsP3 R2 antibody
      • InsP3R2 antibody
      • IP3 R2 antibody
      • IP3 receptor antibody
      • IP3 receptor isoform 2 antibody
      • IP3R 2 antibody
      • IP3R2 antibody
      • ITPR 2 antibody
      • Itpr2 antibody
      • ITPR2_HUMAN antibody
      • Type 2 inositol 1 4 5 trisphosphate receptor antibody
      • Type 2 inositol 1 antibody
      • Type 2 inositol 145 trisphosphate receptor antibody
      • Type 2 InsP3 receptor antibody
      see all

    画像

    • Immunohistochemistry (Frozen sections) - Anti-ITPR2 antibody (ab5805)
      Immunohistochemistry (Frozen sections) - Anti-ITPR2 antibody (ab5805)
      Shows immunolocalization of IP3R-II in rat brain using ab5805.

    参考文献 (3)

    ab5805 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

    ab5805 は 3 報の論文で使用されています。

    • Jaiswal PK  et al. Biochemical characteristics of the chondrocyte-enriched SNORC protein and its transcriptional regulation by SOX9. Sci Rep 10:7790 (2020). PubMed: 32385306
    • Causton B  et al. CARMA3 Mediates Allergic Lung Inflammation in Response to Alternaria alternata. Am J Respir Cell Mol Biol 59:684-694 (2018). PubMed: 29958012
    • Okamoto Y  et al. Arrhythmogenic coupling between the Na+ -Ca2+ exchanger and inositol 1,4,5-triphosphate receptor in rat pulmonary vein cardiomyocytes. J Mol Cell Cardiol 52:988-97 (2012). ICC/IF ; Rat . PubMed: 22285480

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