Anti-IRS1 抗体 (ab5603)

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Key features and details

  • Rabbit polyclonal to IRS1
  • Reacts with: Mouse
  • Isotype: IgG

製品の概要

  • 製品名

    Anti-IRS1 antibody
    IRS1 一次抗体 製品一覧

  • 製品の詳細

    Rabbit polyclonal to IRS1

  • 由来種

    Rabbit

  • 種交差性

    交差種: Mouse
    交差が予測される動物種: Rat, Chicken, Human, Xenopus laevis, African green monkey

  • 免疫原

    Synthetic peptide corresponding to Human IRS1 aa 602-615.
    Sequence:

    LHTDDGYMPMSPGV

    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI

  • 特記事項

    Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

    Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

    We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

    In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

    We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

    Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

    Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

製品の特性

ターゲット情報

  • 機能

    May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit.

  • 関連疾患

    Polymorphisms in IRS1 may be involved in the etiology of non-insulin-dependent diabetes mellitus (NIDDM) [MIM:125853].

  • 配列類似性

    Contains 1 IRS-type PTB domain.
    Contains 1 PH domain.

  • 翻訳後修飾

    Serine phosphorylation of IRS1 is a mechanism for insulin resistance. Ser-312 phosphorylation inhibits insulin action through disruption of IRS1 interaction with the insulin receptor.
    Phosphorylation of Tyr-896 is required for GRB2-binding.
  • Information by UniProt

  • 参照データベース

    see all

  • 別名

    • HIRS 1 antibody
    • HIRS1 antibody
    • Insulin receptor substrate 1 antibody
    • IRS 1 antibody
    • IRS-1 antibody
    • IRS1 antibody
    • IRS1_HUMAN antibody
    • OTTHUMP00000164234 antibody
    see all

参考文献 (29)

ab5603 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

ab5603 は 29 報の論文で使用されています。

  • Han D  et al. Non-cell autonomous promotion of astrogenesis at late embryonic stages by constitutive YAP activation. Sci Rep 10:7041 (2020). PubMed: 32341445
  • de Lucia C  et al. Lifestyle mediates the role of nutrient-sensing pathways in cognitive aging: cellular and epidemiological evidence. Commun Biol 3:157 (2020). PubMed: 32242137
  • Wang B  et al. Mouse bone marrow mesenchymal stem cells with distinct p53 statuses display differential characteristics. Mol Med Rep 21:2051-2062 (2020). PubMed: 32186775
  • Li Z  et al. LncIRS1 controls muscle atrophy via sponging miR-15 family to activate IGF1-PI3K/AKT pathway. J Cachexia Sarcopenia Muscle 10:391-410 (2019). PubMed: 30701698
  • Goudarzi KM  et al. Reduced Expression of PROX1 Transitions Glioblastoma Cells into a Mesenchymal Gene Expression Subtype. Cancer Res 78:5901-5916 (2018). PubMed: 30135192
View all Publications for this product

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