Key features and details
- Rabbit polyclonal to IRS1
- Reacts with: Mouse
- Isotype: IgG
IRS1 一次抗体 製品一覧
製品の詳細Rabbit polyclonal to IRS1
交差が予測される動物種: Rat, Chicken, Human, Xenopus laevis, African green monkey
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保存方法Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
バッファーPreservative: 0.05% Sodium azide
Constituents: 99% PBS, 0.1% BSA
Concentration information loading...
精製度Immunogen affinity purified
機能May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit.
関連疾患Polymorphisms in IRS1 may be involved in the etiology of non-insulin-dependent diabetes mellitus (NIDDM) [MIM:125853].
配列類似性Contains 1 IRS-type PTB domain.
Contains 1 PH domain.
翻訳後修飾Serine phosphorylation of IRS1 is a mechanism for insulin resistance. Ser-312 phosphorylation inhibits insulin action through disruption of IRS1 interaction with the insulin receptor.
Phosphorylation of Tyr-896 is required for GRB2-binding.
- Information by UniProt
- HIRS 1 antibody
- HIRS1 antibody
- Insulin receptor substrate 1 antibody
ab5603 は 29 報の論文で使用されています。
- Han D et al. Non-cell autonomous promotion of astrogenesis at late embryonic stages by constitutive YAP activation. Sci Rep 10:7041 (2020). PubMed: 32341445
- de Lucia C et al. Lifestyle mediates the role of nutrient-sensing pathways in cognitive aging: cellular and epidemiological evidence. Commun Biol 3:157 (2020). PubMed: 32242137
- Wang B et al. Mouse bone marrow mesenchymal stem cells with distinct p53 statuses display differential characteristics. Mol Med Rep 21:2051-2062 (2020). PubMed: 32186775
- Li Z et al. LncIRS1 controls muscle atrophy via sponging miR-15 family to activate IGF1-PI3K/AKT pathway. J Cachexia Sarcopenia Muscle 10:391-410 (2019). PubMed: 30701698
- Goudarzi KM et al. Reduced Expression of PROX1 Transitions Glioblastoma Cells into a Mesenchymal Gene Expression Subtype. Cancer Res 78:5901-5916 (2018). PubMed: 30135192