Anti-IRS1 抗体 (ab5603)

Submit a review Submit a question References (33)

Key features and details

  • Rabbit polyclonal to IRS1
  • Reacts with: Mouse
  • Isotype: IgG

リコンビナント抗体で、ロット間での高い再現性を実現

Product image
Anti-IRS1 antibody [EP263Y] (ab40777)
  • 異なるロット間での安定した再現性
  • 容易なスケールアップ
  • 評価試験による特異性の確認済み
  • 倫理基準に準拠 - アニマル・フリーの生産

製品の概要

  • 製品名

    Anti-IRS1 antibody
    IRS1 一次抗体 製品一覧

  • 製品の詳細

    Rabbit polyclonal to IRS1

  • 由来種

    Rabbit

  • 種交差性

    交差種: Mouse
    交差が予測される動物種: Rat, Chicken, Human, Xenopus laevis, African green monkey

  • 免疫原

    Synthetic peptide corresponding to Human IRS1 aa 602-615.
    Sequence:

    LHTDDGYMPMSPGV

    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI

  • 特記事項

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

    If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

製品の特性

ターゲット情報

  • 機能

    May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit.

  • 関連疾患

    Polymorphisms in IRS1 may be involved in the etiology of non-insulin-dependent diabetes mellitus (NIDDM) [MIM:125853].

  • 配列類似性

    Contains 1 IRS-type PTB domain.
    Contains 1 PH domain.

  • 翻訳後修飾

    Serine phosphorylation of IRS1 is a mechanism for insulin resistance. Ser-312 phosphorylation inhibits insulin action through disruption of IRS1 interaction with the insulin receptor.
    Phosphorylation of Tyr-896 is required for GRB2-binding.
  • Information by UniProt

  • 参照データベース

    see all

  • 別名

    • HIRS 1 antibody
    • HIRS1 antibody
    • Insulin receptor substrate 1 antibody
    • IRS 1 antibody
    • IRS-1 antibody
    • IRS1 antibody
    • IRS1_HUMAN antibody
    • OTTHUMP00000164234 antibody
    see all

参考文献 (33)

ab5603 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

ab5603 は 33 報の論文で使用されています。

  • Han D  et al. Non-cell autonomous promotion of astrogenesis at late embryonic stages by constitutive YAP activation. Sci Rep 10:7041 (2020). PubMed: 32341445
  • de Lucia C  et al. Lifestyle mediates the role of nutrient-sensing pathways in cognitive aging: cellular and epidemiological evidence. Commun Biol 3:157 (2020). PubMed: 32242137
  • Wang B  et al. Mouse bone marrow mesenchymal stem cells with distinct p53 statuses display differential characteristics. Mol Med Rep 21:2051-2062 (2020). PubMed: 32186775
  • Gronska-Peski M  et al. L1cam curbs the differentiation of adult-born hippocampal neurons. Stem Cell Res 48:101999 (2020). PubMed: 32971459
  • Hermida-Prado F  et al. The SRC Inhibitor Dasatinib Induces Stem Cell-Like Properties in Head and Neck Cancer Cells that are Effectively Counteracted by the Mithralog EC-8042. J Clin Med 8:N/A (2019). PubMed: 31382448
View all Publications for this product

レビューと Q&A

Show All レビュー Q&A
レビューを送る 質問を送る

There are currently no Customer reviews or Questions for ab5603.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com