IQDMA, Cell-permeable STAT5 inhibitor (ab141192)
Key features and details
- Cell-permeable STAT5 inhibitor
- CAS Number: 401463-02-3
- Purity: > 98%
- Soluble in DMSO to 100 mM and in ethanol to 100 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
IQDMA, Cell-permeable STAT5 inhibitor -
製品の詳細
Cell-permeable STAT5 inhibitor -
生理活性の詳細
Cell-permeable STAT5 inhibitor (IC50 = 8 μM). Indoloquinoline derivative. Antineoplastic agent with broad spectrum antitumor activity seen in vitro. Induces cell-cycle arrest at the G2/M phase.
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精製度
> 98% -
CAS 番号
401463-02-3 -
構造式
製品の特性
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体系名
N2-11H-Indolo[3,2-c]quinolin-6-yl-N1,N1-dimethyl-1,2-ethanediamine -
分子量
304.39 -
分子式
C19H20N4 -
保存方法
Store at +4°C. The product can be stored for up to 12 months. -
溶解性
Soluble in DMSO to 100 mM and in ethanol to 100 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
CN(C)CCNc2nc1ccccc1c3nc4ccccc4c23 -
由来
Synthetic
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研究分野
関連製品
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プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (3)
ab141192 は 3 報の論文で使用されています。
- Moyama C et al. Stat5b inhibition blocks proliferation and tumorigenicity of glioblastoma stem cells derived from a de novo murine brain cancer model. Am J Cancer Res 12:1129-1142 (2022). PubMed: 35411230
- Sami E et al. The Immunosuppressive Microenvironment in BRCA1-IRIS-Overexpressing TNBC Tumors Is Induced by Bidirectional Interaction with Tumor-Associated Macrophages. Cancer Res 80:1102-1117 (2020). PubMed: 31911557
- Itcho K et al. Angiotensin 1-7 suppresses angiotensin II mediated aldosterone production via JAK/STAT signaling inhibition. J Steroid Biochem Mol Biol 185:137-141 (2019). PubMed: 30125658