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Anti-Interferon gamma 抗体 [GIF-10] (ab9805)

Submit a review Q&A (1)References (3)

Key features and details

  • Mouse monoclonal [GIF-10] to Interferon gamma
  • Reacts with: Human
  • Isotype: IgG1

製品の概要

  • 製品名

    Anti-Interferon gamma antibody [GIF-10]
    Interferon gamma 一次抗体 製品一覧

  • 製品の詳細

    Mouse monoclonal [GIF-10] to Interferon gamma

  • 由来種

    Mouse

  • 種交差性

    交差種: Human

  • 免疫原

    Recombinant full length protein corresponding to Human Interferon gamma.
    Database link: P01579

  • ポジティブ･コントロール

  • 特記事項

    This product was changed from ascites to tissue culture supernatant on 28/11/2017. Please note that the dilutions may need to be adjusted accordingly.

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

    If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

製品の特性

ターゲット情報

  • 機能

    Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.

  • 組織特異性

    Released primarily from activated T lymphocytes.

  • 関連疾患

    In Caucasians, genetic variation in IFNG is associated with the risk of aplastic anemia (AA) [MIM:609135]. AA is a rare disease in which the reduction of the circulating blood cells results from damage to the stem cell pool in bone marrow. In most patients, the stem cell lesion is caused by an autoimmune attack. T-lymphocytes, activated by an endogenous or exogenous, and most often unknown antigenic stimulus, secrete cytokines, including IFN-gamma, which would in turn be able to suppress hematopoiesis.

  • 配列類似性

    Belongs to the type II (or gamma) interferon family.

  • 翻訳後修飾

    Proteolytic processing produces C-terminal heterogeneity, with proteins ending alternatively at Gly-150, Met-157 or Gly-161.

  • 細胞内局在

    Secreted.
  • Information by UniProt

  • 参照データベース

    • 別名

      • IF 1 antibody
      • IFG antibody
      • IFI antibody
      • ifn g antibody
      • IFN gamma antibody
      • IFN immune antibody
      • IFN, immune antibody
      • IFN-gamma antibody
      • IFNG antibody
      • IFNG_HUMAN antibody
      • Immune interferon antibody
      • Interferon gamma antibody
      • Type II Interferon antibody
      see all

    参考文献 (3)

    ab9805 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

    ab9805 は 3 報の論文で使用されています。

    • Osna N  et al. Serum of patients with Guillain-Barre syndrome modulates mitogen-induced cytokine synthesis by normal peripheral blood mononuclear cells. Centr. Eur. J. Immun. 24:82-87 (1999). PubMed:
    • Poluektova L  et al. Immunoregulatory effects of N9-benzyl- and N7-benzyl-8-bromoguanines. Int J Immunopharmacol 21:777-92 (1999). PubMed: 10576622
    • Osna N  et al. Chronic hepatitis C: T-helper1/T-helper2 imbalance could cause virus persistence in peripheral blood. Scand J Clin Lab Invest 57:703-10 (1997). PubMed: 9458493

    レビューと Q&A

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    レビューを送る 質問を送る

    Question

    Unpublished compared to last week ab9657, ab9658. Another possible pair: ab9801, ab9805 (monoclones with different epitopes)? Has this specifically been tested? Sensitivity? Problems in the past with Inteferon gamma detection.

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    Answer

    Yes, antibodies of clones GIF3 and GIF-10 have been used in a sandwich ELISA. The sensitivity of the assay is 300 pg/ml. For the sandwich ELISA, antibody GIF-3 was labelled with biotin. Specific reference for this is Osna N et al. Chronic hepatitis C: T-helper1/T-helper2 imbalance could cause virus persistence in peripheral blood. Scand J Clin Lab Invest 57:703-10 (1997). sELISA. PubMed: 9458493.

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