Anti-Integrin alpha 3 抗体 [IA3] (ab20141)
Key features and details
- Mouse monoclonal [IA3] to Integrin alpha 3
- Suitable for: IHC-Fr, Functional Studies
- Reacts with: Human
- Isotype: IgG1
製品の概要
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製品名
Anti-Integrin alpha 3 antibody [IA3]
Integrin alpha 3 一次抗体 製品一覧 -
製品の詳細
Mouse monoclonal [IA3] to Integrin alpha 3 -
由来種
Mouse -
特異性
Specific to alpha 3 integrin. IA3 is useful for studies on inhibition of cell-cell adhesion and cell-substrate adhesion. -
アプリケーション
適用あり: IHC-Fr, Functional Studiesmore details -
種交差性
交差種: Human -
免疫原
Tissue, cells or virus corresponding to Integrin alpha 3. Transfected human breast epithelial cell line MTSV1-7, hygromycin resistant.
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特記事項
Fusion partner: NS2The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
バッファー
Constituent: PBS -
Concentration information loading... -
精製度
Protein A/G purified -
ポリ/モノ
モノクローナル -
クローン名
IA3 -
アイソタイプ
IgG1 -
軽鎖の種類
unknown -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab20141の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| IHC-Fr |
Use at an assay dependent concentration.
|
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| Functional Studies |
Use at an assay dependent concentration.
|
| 特記事項 |
|---|
|
IHC-Fr
Use at an assay dependent concentration. |
|
Functional Studies
Use at an assay dependent concentration. |
ターゲット情報
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機能
Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. -
組織特異性
Isoform alpha-3A is widely expressed. Isoform alpha-3B is expressed in brain and heart. In brain, both isoforms are exclusively expressed on vascular smooth muscle cells, whereas in heart isoform alpha-3A is strongly expressed on vascular smooth muscle cells, isoform alpha-3B is detected only on endothelial vein cells. -
配列類似性
Belongs to the integrin alpha chain family.
Contains 7 FG-GAP repeats. -
翻訳後修飾
Isoform alpha-3A, but not isoform alpha-3B, is phosphorylated on serine residues. Phosphorylation increases after phorbol 12-myristate 13-acetate stimulation. Isoform alpha-3A is phosphorylated on Tyr-1051. -
細胞内局在
Membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 3675 Human
- Omim: 605025 Human
- SwissProt: P26006 Human
- Unigene: 265829 Human
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別名
- AA407068 antibody
- Antigen identified by monoclonal antibody J143 antibody
- CD49 antigen like family member C antibody
see all
データシートおよび資料
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Datasheet download
参考文献 (2)
ab20141 は 2 報の論文で使用されています。
- Randles MJ et al. Basement membrane ligands initiate distinct signalling networks to direct cell shape. Matrix Biol 90:61-78 (2020). PubMed: 32147508
- Berdichevsky F et al. Branching morphogenesis of human mammary epithelial cells in collagen gels. J Cell Sci 107 ( Pt 12):3557-68 (1994). PubMed: 7535787
