Anti-Integrin alpha 3 抗体 (ab190731)
Key features and details
- Rabbit polyclonal to Integrin alpha 3
- Suitable for: WB
- Reacts with: Mouse, Human
- Isotype: IgG
製品の概要
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製品名
Anti-Integrin alpha 3 antibody
Integrin alpha 3 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to Integrin alpha 3 -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Mouse, Human
交差が予測される動物種: Cow, Chinese hamster -
免疫原
Synthetic peptide corresponding to Human Integrin alpha 3 aa 500-600.
Database link: P26006 -
ポジティブ・コントロール
- HepG2 cell extract.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
バッファー
pH: 7.20
Preservative: 0.05% Sodium azide
Constituent: 99% PBS -
Concentration information loading...
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精製度
Affinity purified -
特記事項(精製)
ab190731 purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Purity >95% by SDS-PAGE. -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Positive Controls
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab190731の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB | (4) |
1/500 - 1/1000. Predicted molecular weight: 117 kDa.
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特記事項 |
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WB
1/500 - 1/1000. Predicted molecular weight: 117 kDa. |
ターゲット情報
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機能
Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. -
組織特異性
Isoform alpha-3A is widely expressed. Isoform alpha-3B is expressed in brain and heart. In brain, both isoforms are exclusively expressed on vascular smooth muscle cells, whereas in heart isoform alpha-3A is strongly expressed on vascular smooth muscle cells, isoform alpha-3B is detected only on endothelial vein cells. -
配列類似性
Belongs to the integrin alpha chain family.
Contains 7 FG-GAP repeats. -
翻訳後修飾
Isoform alpha-3A, but not isoform alpha-3B, is phosphorylated on serine residues. Phosphorylation increases after phorbol 12-myristate 13-acetate stimulation. Isoform alpha-3A is phosphorylated on Tyr-1051. -
細胞内局在
Membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 100758471 Chinese hamster
- Entrez Gene: 508490 Cow
- Entrez Gene: 3675 Human
- Entrez Gene: 16400 Mouse
- Omim: 605025 Human
- SwissProt: P17852 Chinese hamster
- SwissProt: F1MMS9 Cow
- SwissProt: P26006 Human
see all -
別名
- AA407068 antibody
- Antigen identified by monoclonal antibody J143 antibody
- CD49 antigen like family member C antibody
see all
データシートおよび資料
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Datasheet download
参考文献 (7)
ab190731 は 7 報の論文で使用されています。
- Huang L et al. Netrin-1 induces the anti-apoptotic and pro-survival effects of B-ALL cells through the Unc5b-MAPK axis. Cell Commun Signal 20:122 (2022). PubMed: 35974411
- Dadras M et al. Comparative proteomic analysis of osteogenic differentiated human adipose tissue and bone marrow-derived stromal cells. J Cell Mol Med 24:11814-11827 (2020). PubMed: 32885592
- Temoche-Diaz MM et al. Buoyant Density Fractionation of Small Extracellular Vesicle Sub-populations Derived from Mammalian Cells. Bio Protoc 10:e3706 (2020). PubMed: 33659370
- Shen M et al. Tinagl1 Suppresses Triple-Negative Breast Cancer Progression and Metastasis by Simultaneously Inhibiting Integrin/FAK and EGFR Signaling. Cancer Cell 35:64-80.e7 (2019). IP ; Rabbit . PubMed: 30612941
- Temoche-Diaz MM et al. Distinct mechanisms of microRNA sorting into cancer cell-derived extracellular vesicle subtypes. Elife 8:N/A (2019). PubMed: 31436530
- Aleckovic M et al. Identification of Nidogen 1 as a lung metastasis protein through secretome analysis. Genes Dev 31:1439-1455 (2017). PubMed: 28827399
- Hoshino A et al. Tumour exosome integrins determine organotropic metastasis. Nature 527:329-35 (2015). WB ; Human . PubMed: 26524530