Imipramine hydrochloride, Tricyclic antidepressant (ab141046)
Key features and details
- Tricyclic antidepressant
- CAS Number: 113-52-0
- Purity: > 98%
- Soluble in water to 100 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
Imipramine hydrochloride, Tricyclic antidepressant -
製品の詳細
Tricyclic antidepressant -
別名
- Imipramine
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生理活性の詳細
Tricyclic antidepressant with various pharmacological activities. Inhibits reuptake inhibitors (Ki values are 19, 98 and >1000 nM for SERT, NET and DAT, respectively). Muscarinic receptor inhibitor (IC50 = 0.13 μM for M2). Serotonin receptor inhibitor (Ki values are 94 and 160 nM for 5-HT2A and 5-HT2C, respectively). Crosses the blood-brain barrier.
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精製度
> 98% -
CAS 番号
113-52-0 -
構造式
製品の特性
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体系名
10,11-Dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine hydrochloride -
分子量
316.87 -
分子式
C19H24N2.HCl -
PubChem 登録番号
8228 -
保存方法
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in water to 100 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
Cl.CN(C)CCCN2c3ccccc3CCc1ccccc12 -
由来
Synthetic
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研究分野
- Signal Transduction
- Signaling Pathway
- Nuclear Signaling
- Nuclear Hormone Receptors
- Retinoic & Retinoid
- Epigenetics and Nuclear Signaling
- Nuclear Signaling Pathways
- Nuclear Receptors
- Orphan Nuclear Receptors
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (2)
ab141046 は 2 報の論文で使用されています。
- Nollet M Models of Depression: Unpredictable Chronic Mild Stress in Mice. Curr Protoc 1:e208 (2021). PubMed: 34406704
- Yue X et al. TMC Proteins Modulate Egg Laying and Membrane Excitability through a Background Leak Conductance in C. elegans. Neuron 97:571-585.e5 (2018). PubMed: 29395910