製品の概要

  • 製品名

    Iloprost, Prostaglandin (PGI2) analog
  • 製品の詳細

    Prostaglandin (PGI2) analog
  • 別名

    • ZK 36374
  • 生理活性の詳細

    Prostaglandin (PGI2) analog. Binds with high affinity to the human recombinant IP, EP1 and EP3 receptors (Ki values are 11 (IP and EP1) and 56 nM (EP3)). Higher selectivity over other prostanoid receptors.
  • 精製度

    > 97%
  • CAS 番号

    78919-13-8
  • 構造式

    Chemical Structure

製品の特性

  • 体系名

    (5E)-5-[(3aS,4R,5R,6aS)-Hexahydro-5-hydroxy-4-[(1E,3S)-3-hydroxy-4-methyl-1-octen-6-yn-1-yl]-2(1H)-pentalenylidene]pentanoic acid
  • 分子量

    360.49
  • 分子式

    C22H32O4
  • 保存方法

    Store at -20°C (desiccating conditions).
  • 溶解性

    Supplied in methyl acetate (5 mg/ml)
  • 使用に関する注意

    Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES 線形表記

    O[C@@H]1C[C@H](C/2)[C@H](CC2=CCCCC(O)=O)[C@H]1/C=C/[C@@H](O)C(C)CC#CC
  • 由来

    Synthetic

  • 研究分野

参考文献

This product has been referenced in:

  • Della Bella S  et al. Novel mode of action of iloprost: in vitro down-regulation of endothelial cell adhesion molecules. Prostaglandins Other Lipid Mediat 65:73-83 (2001). Read more (PubMed: 11403500) »
  • Abramovitz M  et al. The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta 1483:285-93 (2000). Read more (PubMed: 10634944) »

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