Anti-IL-6 抗体 [B-E8] (ab11449)
Key features and details
- Mouse monoclonal [B-E8] to IL-6
- Reacts with: Human
- Isotype: IgG1
製品の概要
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製品名
Anti-IL-6 antibody [B-E8]
IL-6 一次抗体 製品一覧 -
製品の詳細
Mouse monoclonal [B-E8] to IL-6 -
由来種
Mouse -
種交差性
交差種: Human -
免疫原
Full length protein corresponding to Human IL-6.
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特記事項
Storage in frost free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use.The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
バッファー
pH: 7.20
Preservative: 0.09% Sodium azide
Constituent: PBS -
Concentration information loading... -
精製度
Ion Exchange Chromatography -
特記事項（精製）
Purified IgG prepared by ion exchange chromatography from tissue culture supernatant. -
ポリ/モノ
モノクローナル -
クローン名
B-E8 -
ミエローマ
x63-Ag8.653 -
アイソタイプ
IgG1 -
研究分野
関連製品
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Conjugation kits
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Isotype control
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Recombinant Protein
アプリケーション
追加情報
Is unsuitable for IHC-P.
ターゲット情報
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機能
Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoeitic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. -
関連疾患
Genetic variations in IL6 are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:604302]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.
Note=A IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in HIV-infected men. -
配列類似性
Belongs to the IL-6 superfamily. -
翻訳後修飾
N- and O-glycosylated. -
細胞内局在
Secreted. - Information by UniProt
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参照データベース
- Entrez Gene: 3569 Human
- Omim: 147620 Human
- SwissProt: P05231 Human
- Unigene: 654458 Human
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別名
- Interleukin BSF 2 antibody
- B cell differentiation factor antibody
- B cell stimulatory factor 2 antibody
see all
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (5)
ab11449 は 5 報の論文で使用されています。
- Zhao D et al. Human neural stem cell tropism to metastatic breast cancer. Stem Cells 30:314-25 (2012). PubMed: 22084033
- Cejková J et al. Favorable effects of trehalose on the development of UVB-mediated antioxidant/pro-oxidant imbalance in the corneal epithelium, proinflammatory cytokine and matrix metalloproteinase induction, and heat shock protein 70 expression. Graefes Arch Clin Exp Ophthalmol 249:1185-94 (2011). IHC-Fr ; Rabbit . PubMed: 21494875
- Zenkel M et al. Proinflammatory cytokines are involved in the initiation of the abnormal matrix process in pseudoexfoliation syndrome/glaucoma. Am J Pathol 176:2868-79 (2010). IHC-Fr ; Human . PubMed: 20395431
- Kube D et al. STAT3 is constitutively activated in Hodgkin cell lines. Blood 98:762-70 (2001). Neutralising ; Human . PubMed: 11468177
- Klein B et al. Murine anti-interleukin-6 monoclonal antibody therapy for a patient with plasma cell leukemia. Blood 78:1198-204 (1991). Neutralising ; Human . PubMed: 1715218