Anti-IL-17RA Receptor 抗体 [RM0104-10B27] (ab86487)
Key features and details
- Rat monoclonal [RM0104-10B27] to IL-17RA Receptor
- Suitable for: WB
- Reacts with: Mouse
- Isotype: IgG2
製品の概要
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製品名
Anti-IL-17RA Receptor antibody [RM0104-10B27]
IL-17RA Receptor 一次抗体 製品一覧 -
製品の詳細
Rat monoclonal [RM0104-10B27] to IL-17RA Receptor -
由来種
Rat -
特異性
This antibody detects mouse IL17A Receptor in Western blotting, but not IL17B Receptor.
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アプリケーション
適用あり: WBmore details -
種交差性
交差種: Mouse -
免疫原
Recombinant fragment corresponding to Mouse IL-17RA Receptor (extracellular).
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
バッファー
Constituent: PBS -
Concentration information loading...
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精製度
Protein A purified -
特記事項(精製)
The IgG fraction of culture supernatant was purified by Protein A affinity chromatography. -
ポリ/モノ
モノクローナル -
クローン名
RM0104-10B27 -
アイソタイプ
IgG2 -
研究分野
関連製品
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Compatible Secondaries
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab86487の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB |
Use at an assay dependent concentration.
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特記事項 |
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WB
Use at an assay dependent concentration. |
ターゲット情報
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機能
Receptor for IL17A and IL17F. Binds its IL17A ligand with low affinity, suggesting that additional components are involved in IL17A-induced signaling. -
組織特異性
Widely expressed. -
関連疾患
Defects in IL17RA are the cause of familial candidiasis type 5 (CANDF5) [MIM:613953]. CANDF5 is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans. -
配列類似性
Contains 1 SEFIR domain. -
翻訳後修飾
Glycosylated. -
細胞内局在
Membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 16172 Mouse
- SwissProt: Q60943 Mouse
- Unigene: 4481 Mouse
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別名
- CANDF5 antibody
- CD217 antibody
- CD217 antigen antibody
see all
データシートおよび資料
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Datasheet download
参考文献 (1)
ab86487 は 1 報の論文で使用されています。
- Deguise MO et al. Differential induction of muscle atrophy pathways in two mouse models of spinal muscular atrophy. Sci Rep 6:28846 (2016). WB . PubMed: 27349908