製品の概要

  • 製品名
    Anti-IL-17B Receptor antibody [RM0105-9J28]
    IL-17B Receptor 一次抗体 製品一覧
  • 製品の詳細
    Rat monoclonal [RM0105-9J28] to IL-17B Receptor
  • 由来種
    Rat
  • 特異性
    This antibody detects mouse IL17B Receptor in Western blotting, but not mouse IL17A receptor
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Mouse
  • 免疫原

    Recombinant fragment corresponding to Mouse IL-17B Receptor.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab86488 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/1000. Predicted molecular weight: 56 kDa.

ターゲット情報

  • 関連性
    Recently, a number of cytokines belonging to the interleukin IL-17 family have been identified. These are termed as IL-17B, IL-17C and IL-17E. IL-17 is a potent proinflammatory cytokine that plays roles in a number of diseases including rheumatoid arthritis, multiple sclerosis, and promotion of tumor growth. IL-17B, C, and E like IL-17 are able to induce proinflammatory responses. However, they do not bind to the IL-17 receptor suggesting that additional IL-17R related receptor might exist. Receptor for IL-17B and IL-17E have been independently isolated and have been designated as EV127 (in mouse) and IL-17RH1 (in human), respectively. IL-17E induces activation of NFkB pathway and like IL-17 also induces production of IL-8. IL-17RH1 mRNA is highly expressed in Kidney and liver and at moderate level in small intestine, colon, and brain.
  • 細胞内局在
    Type I membrane protein (isoform 1). Secreted (isoform 2).
  • 参照データベース
  • 別名
    • CRL 4 antibody
    • CRL4 antibody
    • Cytokine receptor CRL4 antibody
    • EVI 27 antibody
    • EVI27 antibody
    • IL 17 receptor B antibody
    • IL 17 receptor homolog 1 antibody
    • IL 17B receptor antibody
    • IL 17RB antibody
    • IL 17Rh1 antibody
    • IL17B Receptor antibody
    • IL17BR antibody
    • IL17RB antibody
    • IL17RH1 antibody
    • Interleukin 17 receptor B antibody
    • Interleukin 17 receptor homolog 1 antibody
    • Interleukin 17 receptor homolog antibody
    • Interleukin 17B receptor antibody
    • MGC5245 antibody
    see all

プロトコール

参考文献

ab86488 has not yet been referenced specifically in any publications.

レビューと Q&A

1-2 of 2 Abreviews or Q&A

Answer

Thank you for your patience.

The subisotype ofab86488 is IgG2a. Thus, the recommended isotype control to be used in flow cytometry would be ab18450.

I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or information.

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Answer

Thank you for contacting us.

Flow cytometry has not yet been tested with this antibody. Therefore, we do not have data to show if and how well it would work in this application. But for UNTESTED species and/or applications, we have established a testing discount program. Here is a brief description of how it works:

The testing discount program is for customers who like to use an antibody/protein on an untested species/application. You would purchase the antibody at full price, test it and submit an Abreview with your data (positive or negative). On your next order you will receive a discount for ONE antibody at the full price (100%) of the antibody you have tested. The terms and conditions applicable to this offer can be found here: https://www.abcam.com/collaborationdiscount.


As isotype control, I would suggest either

ab18450 (rat IgG2a) or ab18541 (rat IgG2b)
https://www.abcam.com/Rat-IgG2a-kappa-monoclonal-aRTK2758-ab18450.html
https://www.abcam.com/Rat-IgG2b-kappa-monoclonal-RTK4530-Isotype-control-ab18541.html

I will check with the lab if they have more information about the specific subisotype of this antibody (2a or 2b).



Please let me know if I shall issue a testing discount code for you.

I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or information.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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