Anti-IL-17A 抗体 (ab9565)
Key features and details
- Rabbit polyclonal to IL-17A
- Suitable for: WB, ELISA
- Reacts with: Human
- Isotype: unknown
製品の概要
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製品名
Anti-IL-17A antibody
IL-17A 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to IL-17A -
由来種
Rabbit -
アプリケーション
適用あり: WB, ELISAmore details -
種交差性
交差種: Human -
免疫原
Highly pure (>98%) recombinant hIL-17 (human Interleukin-17)
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ポジティブ･コントロール
- ウェスタン・ブロット用ポジティブコントロールRecombinant human IL-17 protein
- WB: Recombinant human IL-17A protein (ab9567).
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特記事項
Although some customers have been successful in IHC we no longer batch test in this application.
製品の特性
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製品の状態
Lyophilized:Reconstitute with 200µl of sterile water. Please note that if you receive this product in liquid form it has already been reconstituted as described and no further reconstitution is necessary. -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. -
バッファー
pH: 7.40 -
Concentration information loading... -
精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
unknown -
軽鎖の種類
unknown -
研究分野
関連製品
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Compatible Secondaries
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Positive Controls
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Recombinant Protein
アプリケーション
Our Abpromise guarantee covers the use of ab9565 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB | Use a concentration of 0.1 - 0.2 µg/ml. | |
| ELISA | Use a concentration of 0.5 µg/ml. Allows the detection of 0.2 - 0.4 ng/well of recombinant hIL-17 (assuming 100 µl/well antibody solution). |
ターゲット情報
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機能
Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of the intracellular adhesion molecule-1 (ICAM-1) in fibroblasts. -
組織特異性
Restricted to activated memory T-cells. -
配列類似性
Belongs to the IL-17 family. -
翻訳後修飾
Found both in glycosylated and nonglycosylated forms. -
細胞内局在
Secreted. - Information by UniProt
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参照データベース
- Entrez Gene: 3605 Human
- Omim: 603149 Human
- SwissProt: Q16552 Human
- Unigene: 41724 Human
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別名
- CTLA 8 antibody
- CTLA-8 antibody
- CTLA8 antibody
see all
データシートおよび資料
参考文献 (17)
ab9565 は 17 報の論文で使用されています。
- Li S et al. Tumor-associated neutrophils induce EMT by IL-17a to promote migration and invasion in gastric cancer cells. J Exp Clin Cancer Res 38:6 (2019). PubMed: 30616627
- Orejudo M et al. Interleukin 17A Participates in Renal Inflammation Associated to Experimental and Human Hypertension. Front Pharmacol 10:1015 (2019). PubMed: 31572188
- Othman AA et al. Pharmacokinetics, Safety, and Tolerability of the Dual Inhibitor of Tumor Necrosis Factor-a and Interleukin 17A, ABBV-257, in Healthy Volunteers and Patients With Rheumatoid Arthritis. Clin Pharmacol Drug Dev 8:492-502 (2019). PubMed: 30156758
- Zhao C et al. IL-17 induces NSCLC A549 cell proliferation via the upregulation of HMGA1, resulting in an increased cyclin D1 expression. Int J Oncol N/A:N/A (2018). PubMed: 29512693
- Liu Y et al. MicroRNA-381 reduces inflammation and infiltration of macrophages in polymyositis via downregulating HMGB1. Int J Oncol 53:1332-1342 (2018). PubMed: 29956737
