Anti-IL-1 alpha 抗体 (ab7632)
Key features and details
- Rabbit polyclonal to IL-1 alpha
- Suitable for: ELISA, IHC-Fr, Neutralising, ICC/IF, IHC-P, Flow Cyt, WB
- Reacts with: Mouse, Human
- Isotype: IgG
リコンビナント抗体で、ロット間での高い再現性を実現
- 異なるロット間での安定した再現性
- 容易なスケールアップ
- 評価試験による特異性の確認済み
- 倫理基準に準拠 - アニマル・フリーの生産
製品の概要
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製品名
Anti-IL-1 alpha antibody
IL-1 alpha 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to IL-1 alpha -
由来種
Rabbit -
アプリケーション
適用あり: ELISA, IHC-Fr, Neutralising, ICC/IF, IHC-P, Flow Cyt, WBmore details -
種交差性
交差種: Mouse, Human
交差が予測される動物種: Non human primates -
免疫原
Recombinant full length protein corresponding to Human IL-1 alpha.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
バッファー
Preservative: 0.01% Sodium azide
Constituents: 0.42% Potassium phosphate, 0.87% Sodium chloride -
Concentration information loading...
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精製度
IgG fraction -
特記事項(精製)
whole rabbit serum purified by DEAE fractionation -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Conjugation kits
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab7632の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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ELISA |
Use at an assay dependent concentration.
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IHC-Fr |
Use at an assay dependent concentration.
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Neutralising |
Use at an assay dependent concentration.
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ICC/IF | (2) |
Use at an assay dependent concentration.
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IHC-P |
Use at an assay dependent concentration. PubMed: 22190968
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Flow Cyt | (1) |
Use at an assay dependent concentration.
ab171870 - Rabbit polyclonal IgG, is suitable for use as an isotype control with this antibody. |
WB | (1) |
Use at an assay dependent concentration.
|
特記事項 |
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ELISA
Use at an assay dependent concentration. |
IHC-Fr
Use at an assay dependent concentration. |
Neutralising
Use at an assay dependent concentration. |
ICC/IF
Use at an assay dependent concentration. |
IHC-P
Use at an assay dependent concentration. PubMed: 22190968 |
Flow Cyt
Use at an assay dependent concentration. ab171870 - Rabbit polyclonal IgG, is suitable for use as an isotype control with this antibody. |
WB
Use at an assay dependent concentration. |
ターゲット情報
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機能
Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. -
配列類似性
Belongs to the IL-1 family. -
ドメイン
The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function. -
細胞内局在
Secreted. The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins. - Information by UniProt
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参照データベース
- Entrez Gene: 3552 Human
- Entrez Gene: 16175 Mouse
- Omim: 147760 Human
- SwissProt: P01583 Human
- SwissProt: P01582 Mouse
- Unigene: 1722 Human
- Unigene: 15534 Mouse
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別名
- BAF antibody
- FAF antibody
- Hematopoietin 1 antibody
see all
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (27)
ab7632 は 27 報の論文で使用されています。
- Vitenberga-Verza Z et al. Identification of Inflammatory and Regulatory Cytokines IL-1α-, IL-4-, IL-6-, IL-12-, IL-13-, IL-17A-, TNF-α-, and IFN-γ-Producing Cells in the Milk of Dairy Cows with Subclinical and Clinical Mastitis. Pathogens 11:N/A (2022). PubMed: 35335696
- Collier JJ et al. Pancreatic, but not myeloid-cell, expression of interleukin-1alpha is required for maintenance of insulin secretion and whole body glucose homeostasis. Mol Metab 44:101140 (2021). PubMed: 33285301
- Lu X et al. miR-335-5P contributes to human osteoarthritis by targeting HBP1. Exp Ther Med 21:109 (2021). PubMed: 33335572
- Cao H et al. Inhibition of long non-coding RNA HOXA11-AS against neuroinflammation in Parkinson's disease model via targeting miR-124-3p mediated FSTL1/NF-?B axis. Aging (Albany NY) 13:11455-11469 (2021). PubMed: 33839699
- Wang X et al. A small molecule binding HMGB1 inhibits caspase-11-mediated lethality in sepsis. Cell Death Dis 12:402 (2021). PubMed: 33854044