Anti-IGF2 抗体 (ab18954)
Key features and details
- Rabbit polyclonal to IGF2
- Suitable for: Sandwich ELISA, WB
- Reacts with: Recombinant fragment
- Isotype: IgG
製品の概要
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製品名
Anti-IGF2 antibody
IGF2 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to IGF2 -
由来種
Rabbit -
アプリケーション
適用あり: Sandwich ELISA, WBmore details -
種交差性
交差種: Recombinant fragment -
免疫原
Recombinant full length protein corresponding to Human IGF2. 67 amino acid residues
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特記事項
This product is manufactured by BioVision, an Abcam company and was previously called 5122 IGF-II Antibody. 5122-100 is the same size as the 100 µg size of ab18954.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
バッファー
pH: 7.20
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: PBS, 30% Glycerol (glycerin, glycerine), 0.5% BSA -
Concentration information loading... -
精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
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sELISA pair antibody
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab18954の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| Sandwich ELISA |
Use a concentration of 0.5 µg/ml. Can be paired for Sandwich ELISA with Rat monoclonal [RM0100-3J42] to IGF2 (ab86485).
For sandwich ELISA, use this antibody as Detection at 0.5µg/ml with ab86485 as Capture. |
|
| WB |
Use a concentration of 0.5 - 4 µg/ml. Predicted molecular weight: 20 kDa.
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| 特記事項 |
|---|
|
Sandwich ELISA
Use a concentration of 0.5 µg/ml. Can be paired for Sandwich ELISA with Rat monoclonal [RM0100-3J42] to IGF2 (ab86485). For sandwich ELISA, use this antibody as Detection at 0.5µg/ml with ab86485 as Capture. |
|
WB
Use a concentration of 0.5 - 4 µg/ml. Predicted molecular weight: 20 kDa. |
ターゲット情報
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機能
The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development.
Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3. -
関連疾患
Epigenetic changes of DNA hypomethylation in IGF2 are a cause of Silver-Russell syndrome (SIRS) [MIM:180860]. SIRS is a clinically heterogeneous condition characterized by severe intrauterine growth retardation, poor postnatal growth, craniofacial features such as a triangular shaped face and a broad forehead, body asymmetry, and a variety of minor malformations. -
配列類似性
Belongs to the insulin family. -
翻訳後修飾
O-glycosylated with a core 1 or possibly core 8 glycan. -
細胞内局在
Secreted. - Information by UniProt
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別名
- C11orf43 antibody
- IGF 2 antibody
- IGF II antibody
see all
画像
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Western blot - Anti-IGF2 antibody (ab18954)
Western blot analysis of IGF-II using recombinant human IGF-II.
Lane 1;50ng
Lane 2;250 ng
Lane 3;500 ng
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Sandwich ELISA - Anti-IGF2 antibody (ab18954)
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (1)
ab18954 は 1 報の論文で使用されています。
- Liu G et al. Lnc-MCEI mediated the chemosensitivity of esophageal squamous cell carcinoma via miR-6759-5p to competitively regulate IGF2. Int J Biol Sci 16:2938-2950 (2020). PubMed: 33061807