IB-MECA, A3 agonist (ab120438)
Key features and details
- Highly potent and selective A3 agonist
- CAS Number: 152918-18-8
- Soluble in DMSO to 50 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
IB-MECA, A3 agonist -
製品の詳細
Highly potent and selective A3 agonist -
生理活性の詳細
Highly potent and selective A3 agonist (Ki values are 1.1, 12.6 and 56 nM at A3, A1 and A2A receptors, respectively). Produces potent cardioprotective effects against myocardial injury. Mediates suppression of melanoma cells and suppresses human breast cancer cell proliferation.
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CAS 番号
152918-18-8 -
構造式
製品の特性
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体系名
1-Deoxy-1-[6-[[(3-Iodophenyl)methyl]amino]-9H-purin-9-yl]-N-methyl-β-D-ribofuranuronamide -
分子量
510.29 -
分子式
C18H19IN6O4 -
PubChem 登録番号
123683 -
保存方法
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in DMSO to 50 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
Ic1cccc(c1)CNc4ncnc3c4ncn3[C@@H]2O[C@@H]([C@H](O)C2O)C(=O)NC -
由来
Synthetic
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研究分野
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (2)
ab120438 は 2 報の論文で使用されています。
- Qu F et al. Acupuncture induces adenosine in fibroblasts through energy metabolism and promotes proliferation by activating MAPK signaling pathway via adenosine3 receptor. J Cell Physiol 235:2441-2451 (2020). PubMed: 31556103
- Yi X et al. Adenosine receptors enhance the ATP-induced odontoblastic differentiation of human dental pulp cells. Biochem Biophys Res Commun 497:850-856 (2018). PubMed: 29454963