Anti-HYAL1 抗体 (ab272545)
Key features and details
- Rabbit polyclonal to HYAL1
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
製品の概要
-
製品名
Anti-HYAL1 antibody
HYAL1 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to HYAL1 -
由来種
Rabbit -
Tested Applications & Species
See all applications and species dataApplication Species IHC-P Human
-
免疫原
Recombinant fragment corresponding to Human HYAL1 aa 150-300.
Database link: Q12794 -
ポジティブ･コントロール
- IHC-P: Human gallbladder, kidney and liver tissue.
-
特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing the problem with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation.
One factor contributing to the crisis is the use of antibodies that are not suitable. This can lead to misleading results and the use of incorrect data informing project assumptions and direction. To help address this challenge, we have introduced an application and species grid on our primary antibody datasheets to make it easy to simplify identification of the right antibody for your needs.
Learn more here.
製品の特性
-
製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
バッファー
pH: 7.20
Preservative: 0.02% Sodium azide
Constituents: 40% Glycerol (glycerin, glycerine), PBS -
Concentration information loading... -
精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
-
Compatible Secondaries
アプリケーション
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab272545 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Tested applications are guaranteed to work and covered by our Abpromise guarantee.
Predicted to work for this combination of applications and species but not guaranteed.
Does not work for this combination of applications and species.
| アプリケーション | Species |
|---|---|
| IHC-P |
Human
|
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| IHC-P |
1/50 - 1/200. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
|
| 特記事項 |
|---|
|
IHC-P
1/50 - 1/200. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
ターゲット情報
-
機能
May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth. -
組織特異性
Highly expressed in the liver, kidney and heart. Weakly expressed in lung, placenta and skeletal muscle. No expression detected in adult brain. Isoform 1 is expressed only in bladder and prostate cancer cells, G2/G3 bladder tumor tissues and lymph node specimens showing tumor invasive tumors cells. Isoform 3, isoform 4, isoform 5 and isoform 6 are expressed in normal bladder and bladder tumor tissues. -
関連疾患
Defects in HYAL1 are the cause of mucopolysaccharidosis type 9 (MPS9) [MIM:601492]; also called hyaluronidase deficiency. MPS9 is a lysosomal storage disease characterized by high hyaluronan (HA) concentration in the serum. The clinical features are periarticular soft tissue masses, mild short stature and acetabular erosions, and absence of neurological or visceral involvement. -
配列類似性
Belongs to the glycosyl hydrolase 56 family.
Contains 1 EGF-like domain. -
細胞内局在
Secreted. Lysosome. - Information by UniProt
-
参照データベース
- Entrez Gene: 3373 Human
- Omim: 607071 Human
- SwissProt: Q12794 Human
- Unigene: 75619 Human
-
別名
- HYAL 1 antibody
- Hyal-1 antibody
- HYAL1 antibody
see all
画像
-
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HYAL1 antibody (ab272545)
Paraffin-embedded formalin-fixed human gallbladder tissue stained for HYAL1 using ab272545 1/50 dilution in immunohistochemical analysis.
-
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HYAL1 antibody (ab272545)Paraffin-embedded formalin-fixed human kidney tissue stained for HYAL1 using ab272545 1/50 dilution in immunohistochemical analysis.
-
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HYAL1 antibody (ab272545)Paraffin-embedded formalin-fixed human liver tissue stained for HYAL1 using ab272545 at 1/50 dilution in immunohistochemical analysis.
-
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HYAL1 antibody (ab272545)Paraffin-embedded formalin-fixed human tonsil tissue stained for HYAL1 using ab272545 at 1/50 dilution in immunohistochemical analysis. Shows no expression as expected.
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
-
SDS download
-
Datasheet download
参考文献 (0)
ab272545 は論文での使用が確認できていません。