Key features and details
- Purity: > 95% SDS-PAGE
- Suitable for: Blocking
製品名Human Estrogen Receptor alpha peptide
Estrogen Receptor alpha タンパク質・ペプチド 製品一覧
精製度> 95 % SDS-PAGE.
領域21 to 32
Our Abpromise guarantee covers the use of ab5847 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Blocking - Blocking peptide for Anti-Estrogen Receptor alpha antibody (ab3575)
This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and Human estrogen receptor a, catalog ab3575. Using a solution with equal weights per unit volume of peptide and corresponding antibody will yield a solution with a large molar excess of peptide that is able to competitively bind the antibody.
Concentration information loading...
Shipped at 4°C. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
再構成Reconstitute with 0.1 ml of distilled water.
- 7*/654 isoform
- 7*/819 2 isoform
- 7*/822 isoform
機能Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Can activate the transcriptional activity of TFF1.
配列類似性Belongs to the nuclear hormone receptor family. NR3 subfamily.
Contains 1 nuclear receptor DNA-binding domain.
ドメインComposed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
翻訳後修飾Phosphorylated by cyclin A/CDK2. Phosphorylation probably enhances transcriptional activity.
Glycosylated; contains N-acetylglucosamine, probably O-linked.
Ubiquitinated. Deubiquitinated by OTUB1.
Dimethylated by PRMT1 at Arg-260. The methylation may favor cytoplasmic localization.
Palmitoylated (isoform 3). Not biotinylated (isoform 3).
細胞内局在Nucleus. Cytoplasm. Cell membrane. A minor fraction is associated with the inner membrane and Nucleus. Cytoplasm. Cell membrane. Associated with the inner membrane via palmitoylation.
- Information by UniProt
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab5847 は 2 報の論文で使用されています。
- Oshimo Y et al. Estrogen increases KISS1 expression in newly generated immortalized KISS1-expressing cell line derived from goat preoptic area. J Reprod Dev 67:15-23 (2021). PubMed: 33100283
- Sun T et al. Anxiolytic Effects of 8-O-Acetyl Shanzhiside Methylester on Acute and Chronic Anxiety via Inflammatory Response Inhibition and Excitatory/Inhibitory Transmission Imbalance. Neurotox Res N/A:N/A (2020). PubMed: 32367473