Anti-HHV8 抗体 [LN53] (ab4103)
Key features and details
- Rat monoclonal [LN53] to HHV8
- Suitable for: IHC-P, IHC-Fr
- Reacts with: Species independent
- Isotype: IgG2c
製品の概要
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製品名
Anti-HHV8 antibody [LN53]
HHV8 一次抗体 製品一覧 -
製品の詳細
Rat monoclonal [LN53] to HHV8 -
由来種
Rat -
特異性
HHV 8 is the likely etiological agent of Kaposi’s sarcoma (KS). HHV 8 encodes a latent nuclear antigen (LNA), which is the product of the viral gene orf 73. LNA is capable of forming a complex with retinoblastoma susceptibility gene product, which may be related to its oncogenic activity. -
アプリケーション
適用あり: IHC-P, IHC-Frmore details -
種交差性
交差種: Species independent -
免疫原
Recombinant full length protein corresponding to HHV8. Corresponding to the latent nuclear antigen 1 molecule of HHV 8.
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エピトープ
Located within the ORF-73 region. -
ポジティブ・コントロール
- Kaposi’s sarcoma.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
バッファー
pH: 7.3
Preservative: 0.05% Sodium azide
Constituents: Tissue culture supernatant, 1% BSA -
Concentration information loading...
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精製度
IgG fraction -
ポリ/モノ
モノクローナル -
クローン名
LN53 -
アイソタイプ
IgG2c -
研究分野
関連製品
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Compatible Secondaries
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab4103の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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IHC-P |
1/25 - 1/50. Perform heat mediated antigen retrieval before commencing with IHC staining protocol. ABC method.
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IHC-Fr |
1/25 - 1/50. ABC method.
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特記事項 |
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IHC-P
1/25 - 1/50. Perform heat mediated antigen retrieval before commencing with IHC staining protocol. ABC method. |
IHC-Fr
1/25 - 1/50. ABC method. |
ターゲット情報
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関連性
HHV8 has been found to be associated with three different diseases observed in AIDS patients; kaposi's sarcoma, primary effusion lymphoma (which is a rare type of non-Hodgkin lymphoma affecting the body cavities) and multicentric Castleman's disease. To date there is much evidence to support a direct role for HHV8 in kaposi's sarcoma. -
別名
- HHV 8 antibody
- Human Herpes Virus 8 antibody
- Human herpesvirus 8 antibody
see all
画像
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (9)
ab4103 は 9 報の論文で使用されています。
- Vladimirova O et al. Phase separation and DAXX redistribution contribute to LANA nuclear body and KSHV genome dynamics during latency and reactivation. PLoS Pathog 17:e1009231 (2021). PubMed: 33471863
- Elbasani E et al. Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication Is Independent of Anaphase-Promoting Complex Activity. J Virol 94:N/A (2020). PubMed: 32295923
- Gramolelli S et al. Oncogenic Herpesvirus Engages Endothelial Transcription Factors SOX18 and PROX1 to Increase Viral Genome Copies and Virus Production. Cancer Res 80:3116-3129 (2020). PubMed: 32518203
- Naipauer J et al. PDGFRA defines the mesenchymal stem cell Kaposi's sarcoma progenitors by enabling KSHV oncogenesis in an angiogenic environment. PLoS Pathog 15:e1008221 (2019). PubMed: 31881074
- Tan B et al. Viral and cellular N6-methyladenosine and N6,2'-O-dimethyladenosine epitranscriptomes in the KSHV life cycle. Nat Microbiol 3:108-120 (2018). PubMed: 29109479
- Yang J et al. Case report of ocular Kaposi's sarcoma. BMC Ophthalmol 17:143 (2017). PubMed: 28806949
- Zhu Y et al. An Oncogenic Virus Promotes Cell Survival and Cellular Transformation by Suppressing Glycolysis. PLoS Pathog 12:e1005648 (2016). IHC-P . PubMed: 27187079
- El Hajj H et al. Combination of arsenic and interferon-a inhibits expression of KSHV latent transcripts and synergistically improves survival of mice with primary effusion lymphomas. PLoS One 8:e79474 (2013). ICC/IF . PubMed: 24250827
- Loddenkemper C et al. [The morphologic variants of KSHV/HHV 8-associated lymphoproliferations.] Pathologe : (2006). PubMed: 17160657