Anti-Hepatitis C Virus Core Antigen 抗体 [6A1] (ab2582)

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Key features and details

  • Mouse monoclonal [6A1] to Hepatitis C Virus Core Antigen
  • Suitable for: ELISA, IP
  • Reacts with: Hepatitis C virus
  • Isotype: IgG2a

製品の概要

  • 製品名

    Anti-Hepatitis C Virus Core Antigen antibody [6A1]
    Hepatitis C Virus Core Antigen 一次抗体 製品一覧

  • 製品の詳細

    Mouse monoclonal [6A1] to Hepatitis C Virus Core Antigen

  • 由来種

    Mouse

  • 特異性

    This antibody is specific for Hepatitis C Core Antigen.

  • アプリケーション

    適用あり: ELISA, IPmore details

  • 種交差性

    交差種: Hepatitis C virus

  • 免疫原

    Recombinant fragment, corresponding to amino acids 2-80 of Hepatitis C Virus Core Antigen

  • エピトープ

    This antibody recognises amino acid residues 1-80 of Hepatitis C Core Antigen.

  • 特記事項

    Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

    Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

    We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

    In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

    We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

    Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

    Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab2582 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA 1/10000.
IP Use at an assay dependent concentration.

ターゲット情報

  • 関連性

    The hepatitis C virus (HCV) core protein represents the first 191 amino acids of the viral precursor polyprotein and is cotranslationally inserted into the membrane of the endoplasmic reticulum. Hepatitis C virus (HCV) core is a viral structural protein; it also participates in some cellular processes, including transcriptional regulation. However the mechanisms of core-mediated transcriptional regulation remain poorly understood. Hepatitis C virus (HCV) core protein is thought to contribute to HCV pathogenesis through its interaction with various signal transduction pathways. In addition, HCV core antigen is a recently developed marker of hepatitis C infection. The HCV core protein has been previously shown to circulate in the bloodstream of HCV-infected patients and inhibit host immunity through an interaction with gC1qR. Hepatitis C Virus is a positive, single stranded RNA virus in the Flaviviridae family. The genome is approximately 10,000 nucleotides and encodes a single polyprotein of about 3,000 amino acids. The polyprotein is processed by host cell and viral proteases into three major structural proteins and several non structural proteins necessary for viral replication. Hepatitis C virus (HCV) causes most cases of non-A, non-B hepatitis and results in most HCV infected people developing chronic infections, liver cirrhosis and hepatocellular carcinoma. T cell responses, including interferon-gamma production are severely suppressed in chronic HCV patients.

  • 細胞内局在

    Endoplasmic reticulum

  • 参照データベース

    • 別名

      • Core protein p21 antibody
      • HCV core antigen antibody
      • HCV core protein antibody
      • Hepatitis C Virus core protein antibody

    参考文献 (0)

    ab2582 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

    ab2582 は論文での使用が確認できていません。

    レビューと Q&A

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    Question

    I am interest in Sandwitch ELISA of HCV core protein. Please let me know best combination of your antibody and antigen. I am going to order in your recomendation. Best Regards

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    Answer

    Thank you for your enquiry. Two antibodies against HCV, ab2582 (2 to 80 a.a. epitope) and ab2586 (81 to 120 a.a.) can be used together as a pair for Sandwich ELISA. However, these are both mouse monoclonal IgG2a and so one of these would need to be directly conjugated either with one of our conjugation kits (https://www.abcam.com/kits/antibody-conjugation-kits) or alternatively, we have these clones conjugated to either Biotin, Rhodamine or FITC: Anti-Hepatitis C Virus Core Antigen antibody [1E5] (Biotin) (ab2583) Anti-Hepatitis C Virus Core Antigen antibody [1E5] (FITC) (ab2584) Anti-Hepatitis C Virus Core Antigen antibody [1E5] (Rhodamine) (ab2585) Anti-Hepatitis C Virus Core Antigen antibody [1F6] (Biotin) (ab2587) Anti-Hepatitis C Virus Core Antigen antibody [1F6] (FITC) (ab2588) Anti-Hepatitis C Virus Core Antigen antibody [1F6] (Rhodamine) (ab2589) I hope this information is useful.

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