HENECA, A2A receptor agonist (ab120458)
Key features and details
- Selective A2A receptor agonist
- CAS Number: 141018-30-6
- Soluble in DMSO to 100 mM and in ethanol to 50 mM (with heating)
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
HENECA, A2A receptor agonist -
製品の詳細
Selective A2A receptor agonist -
生理活性の詳細
Selective A2A receptor agonist (Ki = 2.2 nM). Shows good selectivity for A2A over A1 receptors. Displays antiaggregatory activity. Increases cAMP accumulation (EC50 = 43 nM) and inhibits superoxide anion production (EC50 = 3.63 nM) in neutrophils.
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CAS 番号
141018-30-6 -
構造式
製品の特性
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体系名
2-Hexynyladenosine-5'-N-ethylcarboxamide -
分子量
388.42 -
分子式
C18H24N6O4 -
PubChem 登録番号
4438292 -
保存方法
Store at +4°C. The product can be stored for up to 12 months. -
溶解性
Soluble in DMSO to 100 mM and in ethanol to 50 mM (with heating) -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
CCNC(=O)C3OC(n2cnc1c(N)nc(C#CCCCC)nc12)C(O)C3O -
由来
Synthetic
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研究分野
画像
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (1)
ab120458 は 1 報の論文で使用されています。
- Nagpure BV & Bian JS Hydrogen sulfide inhibits A2A adenosine receptor agonist induced ß-amyloid production in SH-SY5Y neuroblastoma cells via a cAMP dependent pathway. PLoS One 9:e88508 (2014). PubMed: 24523906