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  1. Link

    hemoglobin-antibody-haem1-ab401.pdf

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Cardiovascular Blood Blood Cell Antigens RBC Antigens
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Anti-Hemoglobin 抗体 [Haem1] (ab401)

  • Datasheet
  • SDS
Submit a review Q&A (7)References (2)

Product price, shipping and contact information

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出荷および受注について

Shipping info

Promotion Information

Abpromise

保証された製品品質、優れたカスタマー・サポート。 詳細はこちら。

Key features and details

  • Mouse monoclonal [Haem1] to Hemoglobin
  • Suitable for: ELISA, RIA
  • Reacts with: Human
  • Isotype: IgG1

リコンビナント抗体で、ロット間での高い再現性を実現

Product image
Anti-Hemoglobin subunit alpha antibody [EPR3608] (ab92492)
  • 異なるロット間での安定した再現性
  • 容易なスケールアップ
  • 評価試験による特異性の確認済み
  • 倫理基準に準拠 - アニマル・フリーの生産

製品の概要

  • 製品名

    Anti-Hemoglobin antibody [Haem1]
    Hemoglobin 一次抗体 製品一覧
  • 製品の詳細

    Mouse monoclonal [Haem1] to Hemoglobin
  • 由来種

    Mouse
  • 特異性

    hHb - 100% hAlbumin - <0.01% hHaptoglobin - 0.4% hMyoglobin - <0.03% hTransferrin - <0.01% Cross-reactivity values have been calculated on weight/weight basis. They can vary because of the presence of antigen or related impurities in protein preparations used for cross reactivity assays. Affinity constant: 1x1010 l/mol human haemoglobin.
  • アプリケーション

    適用あり: ELISA, RIAmore details
  • 種交差性

    交差種: Human
  • 免疫原

    Full length native protein (purified) (Human).

  • 特記事項

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

    If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

製品の特性

  • 製品の状態

    Liquid
  • 保存方法

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • バッファー

    pH: 6.00
    Preservative: 0.095% Sodium azide
    Constituents: 0.335% PBS, 1.0878% Sodium citrate
  • Concentration information loading...
  • 精製度

    Protein A purified
  • ポリ/モノ

    モノクローナル
  • クローン名

    Haem1
  • ミエローマ

    unknown
  • アイソタイプ

    IgG1
  • 軽鎖の種類

    unknown
  • 研究分野

    • Cardiovascular
    • Blood
    • Blood Cell Antigens
    • RBC Antigens
    • Cardiovascular
    • Blood
    • Other
    • Kits/ Lysates/ Other
    • Kits
    • ELISA Kits
    • ELISA Kits
    • Blood cell antigens ELISA kits

関連製品

  • Compatible Secondaries

    • Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (ab150113)
    • Goat Anti-Mouse IgG H&L (HRP) (ab205719)
  • Isotype control

    • Mouse IgG1, kappa monoclonal [15-6E10A7] - Isotype Control (ab170190)

アプリケーション

The Abpromise guarantee

Abpromise保証は、 次のテスト済みアプリケーションにおけるab401の使用に適用されます

アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。

アプリケーション Abreviews 特記事項
ELISA
Use at an assay dependent concentration.
RIA
Use at an assay dependent concentration.
特記事項
ELISA
Use at an assay dependent concentration.
RIA
Use at an assay dependent concentration.

ターゲット情報

  • 機能

    Involved in oxygen transport from the lung to the various peripheral tissues.
  • 組織特異性

    Red blood cells.
  • 関連疾患

    Defects in HBA1/HBA2 may be a cause of Heinz body anemias (HEIBAN) [MIM:140700]. This is a form of non-spherocytic hemolytic anemia of Dacie type 1. After splenectomy, which has little benefit, basophilic inclusions called Heinz bodies are demonstrable in the erythrocytes. Before splenectomy, diffuse or punctate basophilia may be evident. Most of these cases are probably instances of hemoglobinopathy. The hemoglobin demonstrates heat lability. Heinz bodies are observed also with the Ivemark syndrome (asplenia with cardiovascular anomalies) and with glutathione peroxidase deficiency.
    Defects in HBA1/HBA2 are the cause of alpha-thalassemia (A-THAL) [MIM:604131]. The thalassemias are the most common monogenic diseases and occur mostly in Mediterranean and Southeast Asian populations. The hallmark of alpha-thalassemia is an imbalance in globin-chain production in the adult HbA molecule. The level of alpha chain production can range from none to very nearly normal levels. Deletion of both copies of each of the two alpha-globin genes causes alpha(0)-thalassemia, also known as homozygous alpha thalassemia. Due to the complete absence of alpha chains, the predominant fetal hemoglobin is a tetramer of gamma-chains (Bart hemoglobin) that has essentially no oxygen carrying capacity. This causes oxygen starvation in the fetal tissues leading to prenatal lethality or early neonatal death. The loss of three alpha genes results in high levels of a tetramer of four beta chains (hemoglobin H), causing a severe and life-threatening anemia known as hemoglobin H disease. Untreated, most patients die in childhood or early adolescence. The loss of two alpha genes results in mild alpha-thalassemia, also known as heterozygous alpha-thalassemia. Affected individuals have small red cells and a mild anemia (microcytosis). If three of the four alpha-globin genes are functional, individuals are completely asymptomatic. Some rare forms of alpha-thalassemia are due to point mutations (non-deletional alpha-thalassemia). The thalassemic phenotype is due to unstable globin alpha chains that are rapidly catabolized prior to formation of the alpha-beta heterotetramers.
    Note=Alpha(0)-thalassemia is associated with non-immune hydrops fetalis, a generalized edema of the fetus with fluid accumulation in the body cavities due to non-immune causes. Non-immune hydrops fetalis is not a diagnosis in itself but a symptom, a feature of many genetic disorders, and the end-stage of a wide variety of disorders.
  • 配列類似性

    Belongs to the globin family.
  • 翻訳後修飾

    The initiator Met is not cleaved in variant Thionville and is acetylated.
  • Target information above from: UniProt accession P69905 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • 参照データベース

    • Entrez Gene: 3039 Human
    • Entrez Gene: 3040 Human
    • Entrez Gene: 3043 Human
    • Entrez Gene: 3047 Human
    • Omim: 141800 Human
    • Omim: 141900 Human
    • Omim: 142200 Human
    • SwissProt: P68871 Human
    • SwissProt: P69891 Human
    • SwissProt: P69905 Human
    • Unigene: 449630 Human
    • Unigene: 654744 Human
    see all
  • 別名

    • 3-prime alpha-globin gene antibody
    • A gamma globin antibody
    • Alpha 1 globin antibody
    • Alpha 2 globin antibody
    • Alpha 2 globin chain antibody
    • Alpha globin antibody
    • alpha one globin antibody
    • alpha-1 globin antibody
    • Alpha-globin antibody
    • Beta globin antibody
    • CD113t C antibody
    • CD31 antibody
    • Delta globin antibody
    • Erythremia, beta-globin type, included antibody
    • Gamma 1 globin antibody
    • Gamma A hemoglobin antibody
    • Gamma globin antibody
    • Hb F Agamma antibody
    • HBA 1 antibody
    • HBA 2 antibody
    • HBA antibody
    • HBA T3 antibody
    • HBA-T2 antibody
    • HBA_HUMAN antibody
    • HBA1 antibody
    • HBA2 antibody
    • HBB antibody
    • Hbb-y antibody
    • HBD antibody
    • Hbe1 antibody
    • HBG 1 antibody
    • HBG antibody
    • HBG1 antibody
    • HBGA antibody
    • HBGR antibody
    • HBH antibody
    • Hemoglobin alpha 1 antibody
    • Hemoglobin alpha 1 chain antibody
    • hemoglobin alpha 1 globin chain antibody
    • hemoglobin alpha 2 antibody
    • Hemoglobin alpha chain antibody
    • Hemoglobin alpha locus antibody
    • Hemoglobin alpha locus 1 antibody
    • hemoglobin alpha-1 chain antibody
    • Hemoglobin beta antibody
    • Hemoglobin beta chain antibody
    • Hemoglobin beta chain complex antibody
    • Hemoglobin beta locus antibody
    • Hemoglobin gamma 1 chain antibody
    • Hemoglobin gamma A antibody
    • Hemoglobin gamma A chain antibody
    • Hemoglobin gamma antibody
    • Hemoglobin subunit alpha antibody
    • Hemoglobin subunit beta antibody
    • Hemoglobin subunit gamma 1 antibody
    • hemoglobin, gamma, regulator of antibody
    • Hemoglobin--gamma locus, 136 alanaine antibody
    • HSGGL1 antibody
    • LVV-hemorphin-7 antibody
    • Methemoglobinemia, beta-globin type, included antibody
    • MGC126895 antibody
    • MGC126897 antibody
    • Minor alpha-globin locus antibody
    • PRO2979 antibody
    see all

プロトコール

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

データシートおよび資料

  • SDS download

  • Datasheet download

    Download

参考文献 (2)

ab401 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

ab401 は 2 報の論文で使用されています。

  • Nakazawa H  et al. Coenzyme Q10 protects against burn-induced mitochondrial dysfunction and impaired insulin signaling in mouse skeletal muscle. FEBS Open Bio 9:348-363 (2019). PubMed: 30761259
  • Liu DN  et al. Superior mesenteric artery margin in pancreaticoduodenectomy for pancreatic adenocarcinoma. Oncotarget 8:7766-7776 (2017). PubMed: 27999192

レビューと Q&A

Show All レビュー Q&A
レビューを送る 質問を送る

1-7 of 7 Abreviews or Q&A

Question

Yes,
I will also need to purchase the protein standard.
Thanks,

Read More

Abcam community

Verified customer

Asked on Mar 09 2012

Answer

Thank you for contacting us.

The positive control ab77858 https://www.abcam.com/Hemoglobin-protein-ab77858.html should work with ab401.

Please be advised we have not used these products together. Our assumption is only based on the nature of protein and the immunogen of ab401 raised against. You can buy these products without any hesitation.

I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or information.

Read More

Abcam Scientific Support

Answered on Mar 09 2012

Question

I’m looking for an anti-body for total hemoglobin (human reactivity), but I would like a rabbit polyclonal. Which one would you suggest? If you don’t have a rabbit still suggest one.

Thanks,

Read More

Abcam community

Verified customer

Asked on Mar 09 2012

Answer

Thank you for contacting us.

We do not have rabbit antibody in catalogue we however have mouse monoclonal anti Hemoglobin antibody; the catalogue number is ab401; https://www.abcam.com/Hemoglobin-antibody-Haem1-ab401.html

This antibody is fully guaranteed to be used in ELISA and RIA.

Let me know if you are also interested in purchasing the compatible products of this antibody.I can help finding the one.
I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or information.

Read More

Abcam Scientific Support

Answered on Mar 09 2012

Question

The customer asked if this antibody recognizes adult hemoglobin only (which she would like), or fetal hemoglobin also.

Read More

Abcam community

Verified customer

Asked on May 04 2005

Answer

Thank you for your patience in waiting for a response regarding ab401 and ab402. The source of these antibodies returned my email today and stated that in all likelihood antibodies ab401 and ab402 to human Hemoglobin do not recognize fetal Hb. They have not tested them in their laboratory, but some researchers have results indicating that they do not. Again, I am sorry about the delay and do hesitate to contact us if you have further questions,

Read More

Abcam Scientific Support

Answered on May 17 2005

Question

Customer would like to know for these 3 antibodies, ab9249, ab401, and ab402: do they recognize beta hemoglobin and where is the epitope? He in interested in using them for WB.

Read More

Abcam community

Verified customer

Asked on Dec 29 2003

Answer

Regarding both ab401 and ab402, the epitope has not been identified, but is thought to be in the beta chain. To our knowledge, these antibodies have yet to be tested in Western blotting. All tested applications are specified on Abcam product datasheets. If you decide to go ahead and purchase one of these products, please let us know how you get on and in return we will forward a reward of your choice, typically an Amazon gift voucher. When I receive information regarding ab9249, I will pass the information on to you.

Read More

Abcam Scientific Support

Answered on Dec 29 2003

Question

Dear Sirs, do you offer a ready-to-use anti-human hemoglobin ELISA? I am looking for a possibility to measure the hemoglobin content in cell culture models. Tank you for your information

Read More

Abcam community

Verified customer

Asked on Nov 13 2001

Answer

We stock a number of ELISA kits, but do not currently stock an anti-human hemoglobin ELISA kit.

Read More

Abcam Scientific Support

Answered on Nov 14 2001

Question

In smoke exposure, the blood shows increased levels of carboxyhemoglobin. Any information on antibodies specific for this modified version ?

Read More

Abcam community

Verified customer

Asked on Oct 19 2001

Answer

We believe that antibodies to this modified version of hemoglobin are not commercially available.

Read More

Abcam Scientific Support

Answered on Oct 19 2001

Question

Which is the epitope? alfa or beta chain?

Read More

Abcam community

Verified customer

Asked on Aug 24 2001

Answer

The epitope has not been identified for this antibody, but is thought to be in the beta chain.

Read More

Abcam Scientific Support

Answered on Aug 30 2001

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com

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