Anti-HDAC1 抗体 - ChIP Grade (ab1767)
Key features and details
- Rabbit polyclonal to HDAC1 - ChIP Grade
- Reacts with: Drosophila melanogaster
- Isotype: IgG
製品の概要
-
製品名
Anti-HDAC1 antibody - ChIP Grade
HDAC1 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to HDAC1 - ChIP Grade -
由来種
Rabbit -
種交差性
交差種: Drosophila melanogaster -
免疫原
Synthetic peptide:
C-SGSGTGSGAGAKGAKENNI
, corresponding to amino acids 503-521 of Fruit fly (Drosophila melanogaster) HDAC1 -
特記事項
The SIN3/RPD3 deacetylase complex is essential for G(2) phase cell cycle progression and regulation of SMRTER corepressor levels.
Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.
Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.
製品の特性
-
製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
バッファー
Preservative: 0.02% Sodium azide -
Concentration information loading...
-
精製度
Whole antiserum -
一次抗体 備考
The SIN3/RPD3 deacetylase complex is essential for G(2) phase cell cycle progression and regulation of SMRTER corepressor levels. -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
-
Assay kits
-
ChIP Related Products
-
Compatible Secondaries
-
Isotype control
-
Recombinant Protein
ターゲット情報
-
機能
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. -
組織特異性
Ubiquitous, with higher levels in heart, pancreas and testis, and lower levels in kidney and brain. -
配列類似性
Belongs to the histone deacetylase family. HD type 1 subfamily. -
翻訳後修飾
Sumoylated on Lys-444 and Lys-476; which promotes enzymatic activity. Desumoylated by SENP1.
Phosphorylation on Ser-421 and Ser-423 promotes enzymatic activity and interactions with NuRD and SIN3 complexes.
Ubiquitinated by CHFR, leading to its degradation by the proteasome. -
細胞内局在
Nucleus. - Information by UniProt
-
参照データベース
- Entrez Gene: 38565 Drosophila melanogaster
-
別名
- DKFZp686H12203 antibody
- GON 10 antibody
- HD1 antibody
see all
プロトコール
データシートおよび資料
参考文献 (12)
ab1767 は 12 報の論文で使用されています。
- Panikker P et al. Restoring Tip60 HAT/HDAC2 Balance in the Neurodegenerative Brain Relieves Epigenetic Transcriptional Repression and Reinstates Cognition. J Neurosci 38:4569-4583 (2018). PubMed: 29654189
- Cabezas-Cruz A et al. Anaplasma phagocytophilum increases the levels of histone modifying enzymes to inhibit cell apoptosis and facilitate pathogen infection in the tick vector Ixodes scapularis. Epigenetics 11:303-19 (2016). PubMed: 27019326
- Eberle AB et al. An Interaction between RRP6 and SU(VAR)3-9 Targets RRP6 to Heterochromatin and Contributes to Heterochromatin Maintenance in Drosophila melanogaster. PLoS Genet 11:e1005523 (2015). PubMed: 26389589
- Ji Z et al. The forkhead transcription factor FOXK2 acts as a chromatin targeting factor for the BAP1-containing histone deubiquitinase complex. Nucleic Acids Res 42:6232-42 (2014). WB . PubMed: 24748658
- Fitzsimons HL et al. The histone deacetylase HDAC4 regulates long-term memory in Drosophila. PLoS One 8:e83903 (2013). ICC/IF ; Drosophila melanogaster . PubMed: 24349558