製品の概要

  • 製品名

    HC-030031, TRPA1 blocker
  • 製品の詳細

    TRPA1 blocker, orally active
  • 生理活性の詳細

    Selective TRPA1 blocker, orally active. Blocks TRPA1-mediated currents (IC50 = 0.7 μM) and selective over TRPV1, TRPV3, TRPV4, hERG, and NaV1.2 channels (IC50 >10 μM). Does not display any significant binding to 41 other receptors, ion channels, and transporters nor functional modulation of 7 enzymes that are known to modulate pain signaling.
  • 精製度

    > 99%
  • CAS 番号

    349085-38-7
  • 構造式

    Chemical Structure

製品の特性

参考文献

This product has been referenced in:

See 1 Publication for this product

レビューと Q&A

Answer

Thank you for your enquiry.

I am sorry we have no information from our own testing or from customers regarding the use of ab120554 HC-030031for intrathecal administration in rats.

I have done a general literature search for hc-030031 intrathecal administration in rats. The following publication indicates they have used 100 and300 mg/kg, suspended in 0.5% Methylcellulose and the drug was dosed p.o. at a volume of 10 ml/kg.

HC-030031, a TRPA1 selective antagonist, attenuates inflammatory- and neuropathy-induced mechanical hypersensitivity
Samer R Eid
Molecular Pain 2008, 4:48
http://www.molecularpain.com/content/4/1/48

For more information, I can recommend to try a more extensive literature search:
https://www.google.com/search?q=intrathecal+administration+HC-030031&ie=utf-8&oe=utf-8&aq=t&rls=org.mozilla:en-GB:official&client=firefox-a

I hope this will be helpful to you. If you require any further information, please do not hesitate to contact us.

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