GW 3965 hydrochloride, LXR agonist (ab141299)
Key features and details
- Potent and selective LXR agonist
- CAS Number: 405911-17-3
- Purity: > 98%
- Soluble in DMSO to 100 mM and in ethanol to 25 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
GW 3965 hydrochloride, LXR agonist -
製品の詳細
Potent and selective LXR agonist -
生理活性の詳細
Potent and selective LXR agonist (EC50 values are 190 and 30 nM at hLXRα and hLXRβ, respectively). Reduces Ang II-mediated vasopressor responses in rats. Orally active. Anti-inflammatory, Hypolipidemic and antitumor agent. Active in vivo and in vitro.
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精製度
> 98% -
CAS 番号
405911-17-3 -
構造式
製品の特性
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体系名
3-[3-[[[2-Chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino]propoxy]benzeneacetic acid hydrochloride -
分子量
618.52 -
分子式
C33H31ClF3NO3.HCl -
PubChem 登録番号
16078973 -
保存方法
Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in DMSO to 100 mM and in ethanol to 25 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
Cl.Clc4c(cccc4CN(CCCOc1cc(CC(=O)O)ccc1)CC(c2ccccc2)c3ccccc3)C(F)(F)F -
由来
Synthetic
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研究分野
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (1)
ab141299 は 1 報の論文で使用されています。
- Zhang G et al. Placental mechanism of prenatal nicotine exposure-reduced blood cholesterol levels in female fetal rats. Toxicol Lett 296:31-38 (2018). PubMed: 30036686