GsMTx-4, mechanosensitive and stretch-activated ion channel inhibitor (ab141871)
Key features and details
- Mechanosensitive and stretch-activated ion channel inhibitor
- CAS Number: 1209500-46-8
Soluble in water to 1mg/ml
- Form / State: Solid
- Source: Grammostola rosea
製品の概要
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製品名
GsMTx-4, mechanosensitive and stretch-activated ion channel inhibitor -
製品の詳細
Mechanosensitive and stretch-activated ion channel inhibitor -
CAS 番号
1209500-46-8 -
構造式
製品の特性
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分子量
4095.85 -
分子式
C185H273N49O45S6 -
配列
GCLEFWWKCNPNDDKCCRPKLKCSKLFKLCNFSF (Modifications: Phe-34 = C-terminal amide, Disulfide bridges: 2-17, 9-23 and 16-30)
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PubChem 登録番号
90488987 -
保存方法
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in water to 1mg/ml
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使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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由来
Grammostola rosea
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研究分野
画像
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2D chemical structure image of ab141871, GsMTx-4, mechanosensitive and stretch-activated ion channel inhibitor
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GsMTx-4 (ab141870) inhibits NaV1.7 channel currents expressed in Xenopus oocytes. NaV1.7 currents were elicited by 100 ms voltage ramp from a holding potential of -100 mV to +30 mV, applied every 10 seconds using whole-cell voltage clamp technique. Left: Superimposed traces of NaV1.7 currents before (black) and during (green) application of 500 nM GsMTx-4 (ab141870). Right: GsMTx-4 dose response inhibition of NaV1.7 currents.
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (29)
ab141871 は 29 報の論文で使用されています。
- Shen X et al. A regulatory role of Piezo1 in apoptosis of periodontal tissue and periodontal ligament fibroblasts during orthodontic tooth movement. Aust Endod J 49 Suppl 1:228-237 (2023). PubMed: 36461169
- Luo M et al. Chemical Activation of Piezo1 Alters Biomechanical Behaviors toward Relaxation of Cultured Airway Smooth Muscle Cells. Biol Pharm Bull 46:1-11 (2023). PubMed: 36596517
- Gonçalves AN et al. Intraluminal chloride regulates lung branching morphogenesis: involvement of PIEZO1/PIEZO2. Respir Res 24:42 (2023). PubMed: 36740669
- Zhu T et al. The mechanosensitive ion channel Piezo1 modulates the migration and immune response of microglia. iScience 26:105993 (2023). PubMed: 36798430
- Lopez-Cavestany M et al. Matrix stiffness induces epithelial-to-mesenchymal transition via Piezo1-regulated calcium flux in prostate cancer cells. iScience 26:106275 (2023). PubMed: 36950111