Key features and details
- Goat polyclonal to GPR2/CCR10
- Suitable for: IHC-P
- Reacts with: Mouse
- Isotype: IgG
GPR2/CCR10 一次抗体 製品一覧
製品の詳細Goat polyclonal to GPR2/CCR10
特異性Peptide sequence is < 50 % identical to other mouse chemokine receptors in this region.
アプリケーション適用あり: IHC-Pmore details
- Mouse lymph nodes or small intestine.
Receptors for the C-C chemokine family include CCR-1, CCR-2A, CCR-3, CCR-4, CCR-5 and the Duffy blood group antigen. The C-C receptors are important in the function of T cell chemotaxis and migration of phagocytic cells to sites of inflammation. CCR10 in particular is the receptor for the skin-associated CC chemokine CCL27 (CTACK) as well as the novel chemokine CCL28 which displays chemotactic activity for resting CD4+ and CD8+ T cells.
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We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
バッファーPreservative: 0.1% Sodium azide
Constituent: 0.1% BSA
Concentration information loading...
精製度Immunogen affinity purified
一次抗体 備考Receptors for the C-C chemokine family include CCR-1, CCR-2A, CCR-3, CCR-4, CCR-5 and the Duffy blood group antigen. The C-C receptors are important in the function of T cell chemotaxis and migration of phagocytic cells to sites of inflammation. CCR10 in particular is the receptor for the skin-associated CC chemokine CCL27 (CTACK) as well as the novel chemokine CCL28 which displays chemotactic activity for resting CD4+ and CD8+ T cells.
Our Abpromise guarantee covers the use of ab1661 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
機能Receptor for chemokines SCYA27 and SCYA28. Subsequently transduces a signal by increasing the intracellular calcium ions level and stimulates chemotaxis in a pre-B cell line.
組織特異性Expressed at high levels in adult testis, small intestine, fetal lung, fetal kidney. Weaker expression was observed in many other adult tissues including spleen, thymus, lymph node, Peyer patches, colon, heart, ovary, peripheral blood lymphocytes, thyroid and spinal cord. Also expressed by melanocytes, dermal fibroblasts, dermal microvascular endothelial cells. Also detected in T-cells and in skin-derived Langerhans cells.
配列類似性Belongs to the G-protein coupled receptor 1 family.
- Information by UniProt
- C C chemokine receptor type 10 antibody
- C-C chemokine receptor type 10 antibody
- C-C CKR-10 antibody
ab1661 は 7 報の論文で使用されています。
- Hu K et al. CCL19 and CCL28 augment mucosal and systemic immune responses to HIV-1 gp140 by mobilizing responsive immunocytes into secondary lymph nodes and mucosal tissue. J Immunol 191:1935-47 (2013). PubMed: 23858028
- Shankar SP et al. RGS16 attenuates pulmonary Th2/Th17 inflammatory responses. J Immunol 188:6347-56 (2012). ICC ; Mouse . PubMed: 22593615
- Kutzler MA et al. Plasmids encoding the mucosal chemokines CCL27 and CCL28 are effective adjuvants in eliciting antigen-specific immunity in vivo. Gene Ther 17:72-82 (2010). Mouse . PubMed: 19847203
- Cornejo MG et al. Constitutive JAK3 activation induces lymphoproliferative syndromes in murine bone marrow transplantation models. Blood 113:2746-54 (2009). IHC-P ; Mouse . PubMed: 19139084
- Kagami S et al. CCL27-transgenic mice show enhanced contact hypersensitivity to Th2, but not Th1 stimuli. Eur J Immunol 38:647-57 (2008). PubMed: 18266301
- Liu JX et al. CCR7, CCR8, CCR9 and CCR10 in the mouse hippocampal CA1 area and the dentate gyrus during and after pilocarpine-induced status epilepticus. J Neurochem 100:1072-88 (2007). PubMed: 17181556
- Chen L et al. CCL27 is a critical factor for the development of atopic dermatitis in the keratin-14 IL-4 transgenic mouse model. Int Immunol 18:1233-42 (2006). PubMed: 16735375