Go 6976, PKC inhibitor (ab141413)
Key features and details
- Potent PKC inhibitor. Selective for PKCα and PKCβ
- CAS Number: 136194-77-9
- Purity: > 99%
- Soluble in DMSO to 10 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
Go 6976, PKC inhibitor -
製品の詳細
Potent PKC inhibitor. Selective for PKCα and PKCβ -
精製度
> 99% -
特記事項
This product is manufactured by BioVision, an Abcam company and was previously called 1711 Gö 6976. 1711-500 is the same size as the 500 µg size of ab141413.
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CAS 番号
136194-77-9 -
構造式
製品の特性
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体系名
5,6,7,13-Tetrahydro-13-methyl-5-oxo-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-12-propanenitrile -
分子量
378.43 -
分子式
C24H18N4O -
PubChem 登録番号
3501 -
保存方法
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in DMSO to 10 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
CN1C2=CC=CC=C2C3=C4C(=C5C6=CC=CC=C6N(C5=C31)CCC#N)CNC4=O -
由来
Synthetic
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研究分野
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (8)
ab141413 は 8 報の論文で使用されています。
- Zhang H et al. Signaling pathways involved in NMDA-induced suppression of M-channels in corticotropin-releasing hormone neurons in central amygdala. J Neurochem 161:478-491 (2022). PubMed: 35583089
- Qian A et al. A rapid degradation of calponin 2 is required for cytokinesis. Am J Physiol Cell Physiol 321:C355-C368 (2021). PubMed: 34133238
- Jeong J et al. Inhibition of ezrin causes PKCa-mediated internalization of erbb2/HER2 tyrosine kinase in breast cancer cells. J Biol Chem 294:887-901 (2019). PubMed: 30463939
- Yang WC et al. Therapeutic hypercapnia reduces blood-brain barrier damage possibly via protein kinase Ce in rats with lateral fluid percussion injury. J Neuroinflammation 16:36 (2019). PubMed: 30760300
- Xue X et al. Protein kinase Ca drives fibroblast activation and kidney fibrosis by stimulating autophagic flux. J Biol Chem 293:11119-11130 (2018). PubMed: 29794026
- Ren J et al. Rictor/mammalian target of rapamycin complex 2 promotes macrophage activation and kidney fibrosis. J Pathol 242:488-499 (2017). PubMed: 28585302
- Pacitto R et al. CXCL12-induced macropinocytosis modulates two distinct pathways to activate mTORC1 in macrophages. J Leukoc Biol 101:683-692 (2017). PubMed: 28250113
- Gu Y et al. Epac-protein kinase C alpha signaling in purinergic P2X3R-mediated hyperalgesia after inflammation. Pain 157:1541-50 (2016). PubMed: 26963850