Anti-GNB1 抗体 (ab3433)

Submit a review Submit a question
Western blot - Anti-GNB1 antibody (ab3433)

    Key features and details

    • Rabbit polyclonal to GNB1
    • Suitable for: WB
    • Reacts with: Sheep
    • Isotype: IgG

    製品の概要

    • 製品名

      Anti-GNB1 antibody
      GNB1 一次抗体 製品一覧

    • 製品の詳細

      Rabbit polyclonal to GNB1

    • 由来種

      Rabbit

    • アプリケーション

      適用あり: WBmore details

    • 種交差性

      交差種: Sheep
      交差が予測される動物種: Rat, Dog, Xenopus laevis, Zebrafish, Amphibian, Chinese hamster

    • 免疫原

      Synthetic peptide corresponding to Human GNB1 aa 8-25.
      Sequence:

      RQEAEQLKNQIRDARKAC


      (Peptide available as ab4972)
      Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI

    • 特記事項

      The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

      If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

    製品の特性

    • 製品の状態

      Liquid

    • 保存方法

      Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    • バッファー

      Preservative: 0.05% Sodium azide
      Constituents: 0.1% BSA, 99% PBS
    • Concentration information loading...

    • 精製度

      Immunogen affinity purified

    • 一次抗体 備考

      Vision involves the conversion of light into electrochemical signals that are processed by the retina and subsequently sent to, and interpreted by, the brain. The process of converting light into an electrochemical signal begins when the membrane-bound protein, rhodopsin, absorbs light within the retina. Photoexcitation of rhodopsin causes the cytoplasmic surface of the protein to become catalytically active. In the active state, rhodopsin activates transducin, a GTP binding protein. Once activated, transducin promotes the hydrolysis of cGMP by phosphodiesterase (PDE). The decrease of intracellular cGMP concentration causes the ion channels within the outer segment of the rod or cone to close, thus causing membrane hyperpolarization and, eventually, signal transmission. Rhodopsin activity is believed to be shut off by phosphorylation followed by binding of the soluble protein, arrestin. Transducin, once activated by rhodopsin, promotes the hydrolysis of cGMP by PDE. The subunit composition of transducin differs between different photoreceptor cells. Rod transducin consists of rod transducin alpha (Tr alpha), T beta, and T gamma. Cone transducin is composed of cone transducin alpha (Tc alpha), T beta and T gamma. Differential transducin subunit composition of transducin is believed to be responsible for the different light sensitivities between photoreceptive cells.

    • ポリ/モノ

      ポリクローナル

    • アイソタイプ

      IgG

    • 研究分野

    アプリケーション

    The Abpromise guarantee

    Abpromise保証は、 次のテスト済みアプリケーションにおけるab3433の使用に適用されます

    アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。

    アプリケーション Abreviews 特記事項
    WB
    Use a concentration of 2 µg/ml.
    特記事項
    WB
    Use a concentration of 2 µg/ml.

    ターゲット情報

    • 機能

      Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

    • 配列類似性

      Belongs to the WD repeat G protein beta family.
      Contains 7 WD repeats.

    • 翻訳後修飾

      Phosphorylation at His-266 by NDKB contributes to G protein activation by increasing the high energetic phosphate transfer onto GDP.
    • Information by UniProt

    • 参照データベース

      • 別名

        • Beta subunit signal transducing proteins GS/GI antibody
        • G protein beta 1 subunit antibody
        • GBB1 antibody
        • GBB1_HUMAN antibody
        • gnb1 antibody
        • Guanine nucleotide binding protein (G protein) beta polypeptide 1 antibody
        • Guanine nucleotide binding protein beta 1 subunit antibody
        • Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 antibody
        • Transducin beta chain 1 antibody
        see all

      画像

      • Western blot - Anti-GNB1 antibody (ab3433)
        Western blot - Anti-GNB1 antibody (ab3433)
        Western blot of Tr beta on sheep retinal extracts using ab3433. Western blot of GNB1 on sheep retinal extracts using ab3433.

      参考文献 (0)

      ab3433 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

      ab3433 は論文での使用が確認できていません。

      レビューと Q&A

      Show All レビュー Q&A
      レビューを送る 質問を送る

      There are currently no Customer reviews or Questions for ab3433.
      Please use the links above to contact us or submit feedback about this product.

      Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
      For licensing inquiries, please contact partnerships@abcam.com