Anti-GNB1 抗体 (ab3433)
Key features and details
- Rabbit polyclonal to GNB1
- Suitable for: WB
- Reacts with: Mouse, Sheep, Cow, Human, Drosophila melanogaster
- Isotype: IgG
製品の概要
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製品名
Anti-GNB1 antibody
GNB1 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to GNB1 -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Mouse, Sheep, Cow, Human, Drosophila melanogaster
交差が予測される動物種: Rat, Dog, Xenopus laevis, Zebrafish, Amphibian, Chinese hamster -
免疫原
Synthetic peptide corresponding to Human GNB1 aa 8-25.
Sequence:RQEAEQLKNQIRDARKAC
(Peptide available asab4972) -
特記事項
Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.
Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
バッファー
Preservative: 0.05% Sodium azide
Constituents: 0.1% BSA, 99% PBS -
Concentration information loading...
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精製度
Immunogen affinity purified -
一次抗体 備考
Vision involves the conversion of light into electrochemical signals that are processed by the retina and subsequently sent to, and interpreted by, the brain. The process of converting light into an electrochemical signal begins when the membrane-bound protein, rhodopsin, absorbs light within the retina. Photoexcitation of rhodopsin causes the cytoplasmic surface of the protein to become catalytically active. In the active state, rhodopsin activates transducin, a GTP binding protein. Once activated, transducin promotes the hydrolysis of cGMP by phosphodiesterase (PDE). The decrease of intracellular cGMP concentration causes the ion channels within the outer segment of the rod or cone to close, thus causing membrane hyperpolarization and, eventually, signal transmission. Rhodopsin activity is believed to be shut off by phosphorylation followed by binding of the soluble protein, arrestin. Transducin, once activated by rhodopsin, promotes the hydrolysis of cGMP by PDE. The subunit composition of transducin differs between different photoreceptor cells. Rod transducin consists of rod transducin alpha (Tr alpha), T beta, and T gamma. Cone transducin is composed of cone transducin alpha (Tc alpha), T beta and T gamma. Differential transducin subunit composition of transducin is believed to be responsible for the different light sensitivities between photoreceptive cells. -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
Our Abpromise guarantee covers the use of ab3433 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
アプリケーション | Abreviews | 特記事項 |
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WB | Use a concentration of 2 µg/ml. |
ターゲット情報
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機能
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. -
配列類似性
Belongs to the WD repeat G protein beta family.
Contains 7 WD repeats. -
翻訳後修飾
Phosphorylation at His-266 by NDKB contributes to G protein activation by increasing the high energetic phosphate transfer onto GDP. - Information by UniProt
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参照データベース
- Entrez Gene: 2782 Human
- Entrez Gene: 14688 Mouse
- Entrez Gene: 24400 Rat
- Entrez Gene: 322104 Zebrafish
- Omim: 139380 Human
- SwissProt: P62871 Cow
- SwissProt: P62873 Human
- SwissProt: P62874 Mouse
see all -
別名
- Beta subunit signal transducing proteins GS/GI antibody
- G protein beta 1 subunit antibody
- GBB1 antibody
see all
画像
データシートおよび資料
参考文献 (0)
ab3433 は論文での使用が確認できていません。