Anti-GNAQ 抗体 (ab128060)
Key features and details
- Goat polyclonal to GNAQ
- Suitable for: WB, IHC-P
- Reacts with: Rat, Human
- Isotype: IgG
リコンビナント抗体で、ロット間での高い再現性を実現
- 異なるロット間での安定した再現性
- 容易なスケールアップ
- 評価試験による特異性の確認済み
- 倫理基準に準拠 - アニマル・フリーの生産
製品の概要
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製品名
Anti-GNAQ antibody
GNAQ 一次抗体 製品一覧 -
製品の詳細
Goat polyclonal to GNAQ -
由来種
Goat -
アプリケーション
適用あり: WB, IHC-Pmore details -
種交差性
交差種: Rat, Human
交差が予測される動物種: Hamster, Cow, Dog, Pig, Monkey, a wide range of other species -
免疫原
Synthetic peptide:
NDLDRVADPAYLPT
with a Cysteine residue linker, corresponding to internal sequence amino acids 162-175 of Human GNAQ. -
特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. -
バッファー
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 99% Tris buffered saline, 0.5% BSA -
Concentration information loading...
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精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Positive Controls
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab128060の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB |
Use a concentration of 0.1 - 0.3 µg/ml. Detects a band of approximately 38-40 kDa (predicted molecular weight: 42 kDa).
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IHC-P |
Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
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特記事項 |
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WB
Use a concentration of 0.1 - 0.3 µg/ml. Detects a band of approximately 38-40 kDa (predicted molecular weight: 42 kDa). |
IHC-P
Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
ターゲット情報
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機能
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. -
組織特異性
Predominantly expressed in ovary, prostate, testis and colon. -
配列類似性
Belongs to the G-alpha family. G(q) subfamily. - Information by UniProt
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参照データベース
- Entrez Gene: 536654 Cow
- Entrez Gene: 403928 Dog
- Entrez Gene: 2776 Human
- Entrez Gene: 654405 Pig
- Entrez Gene: 81666 Rat
- Omim: 600998 Human
- SwissProt: Q28294 Dog
- SwissProt: P50148 Human
see all -
別名
- CMC1 antibody
- G alpha Q antibody
- G protein alpha Q antibody
see all
画像
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (6)
ab128060 は 6 報の論文で使用されています。
- Kawakami K et al. Heterotrimeric Gq proteins act as a switch for GRK5/6 selectivity underlying β-arrestin transducer bias. Nat Commun 13:487 (2022). PubMed: 35078997
- Kusumoto J et al. OPN4 belongs to the photosensitive system of the human skin. Genes Cells 25:215-225 (2020). PubMed: 31989708
- Inoue A et al. Illuminating G-Protein-Coupling Selectivity of GPCRs. Cell 177:1933-1947.e25 (2019). PubMed: 31160049
- Chiang NY et al. GPR56/ADGRG1 Activation Promotes Melanoma Cell Migration via NTF Dissociation and CTF-Mediated Ga12/13/RhoA Signaling. J Invest Dermatol 137:727-736 (2017). PubMed: 27818281
- Devost D et al. Conformational Profiling of the AT1 Angiotensin II Receptor Reflects Biased Agonism, G Protein Coupling, and Cellular Context. J Biol Chem 292:5443-5456 (2017). PubMed: 28213525
- Hughes S et al. Using siRNA to define functional interactions between melanopsin and multiple G Protein partners. Cell Mol Life Sci 72:165-79 (2015). IHC . PubMed: 24958088