Anti-GDNF 抗体 (ab18956)
Key features and details
- Rabbit polyclonal to GDNF
- Suitable for: IHC-P, IHC-Fr, IP, WB
- Reacts with: Mouse, Human
- Isotype: IgG
製品の概要
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製品名
Anti-GDNF antibody
GDNF 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to GDNF -
由来種
Rabbit -
特異性
GDNF homodimerizes and has 5 isoforms along with a signal and propeptide, so there is a potential for multiple bands in western blot. -
アプリケーション
適用あり: IHC-P, IHC-Fr, IP, WBmore details -
種交差性
交差種: Mouse, Human -
免疫原
Synthetic peptide surrounding amino acid 195 of mouse GDNF.(Peptide available as ab51926.)
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特記事項
This product is manufactured by BioVision, an Abcam company and was previously called 5098 GDNF Antibody. 5098-100 is the same size as the 100 µg size of ab18956.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. -
バッファー
Preservative: 0.03% Proclin 300
Constituents: PBS, 30% Glycerol (glycerin, glycerine), 0.5% BSA, 0.015% EDTA -
Concentration information loading... -
精製度
Protein A purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab18956の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| IHC-P | (5) |
Use at an assay dependent concentration.
|
| IHC-Fr | (1) |
Use at an assay dependent concentration.
|
| IP |
Use at an assay dependent concentration.
|
|
| WB | (1) |
Use at an assay dependent concentration. Predicted molecular weight: 24 kDa.
Western blot may give multiple bands. GDNF homodimerizes and has 5 isoforms along with a signal and propeptide. |
| 特記事項 |
|---|
|
IHC-P
Use at an assay dependent concentration. |
|
IHC-Fr
Use at an assay dependent concentration. |
|
IP
Use at an assay dependent concentration. |
|
WB
Use at an assay dependent concentration. Predicted molecular weight: 24 kDa. Western blot may give multiple bands. GDNF homodimerizes and has 5 isoforms along with a signal and propeptide. |
ターゲット情報
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機能
Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. -
組織特異性
In the brain, predominantly expressed in the striatum with highest levels in the caudate and lowest in the putamen. -
関連疾患
Defects in GDNF may be a cause of Hirschsprung disease (HSCR) [MIM:142623]. In association with mutations of RET gene, defects in GDNF may be involved in Hirschsprung disease. This genetic disorder of neural crest development is characterized by the absence of intramural ganglion cells in the hindgut, often resulting in intestinal obstruction.
Defects in GDNF are a cause of congenital central hypoventilation syndrome (CCHS) [MIM:209880]; also known as congenital failure of autonomic control or Ondine curse. CCHS is a rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia. -
配列類似性
Belongs to the TGF-beta family. GDNF subfamily. -
細胞内局在
Secreted. - Information by UniProt
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参照データベース
- Entrez Gene: 2668 Human
- Entrez Gene: 14573 Mouse
- Omim: 600837 Human
- SwissProt: P39905 Human
- SwissProt: P48540 Mouse
- Unigene: 248114 Human
- Unigene: 4679 Mouse
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別名
- Astrocyte derived trophic factor antibody
- Astrocyte derived trophic factor 1 antibody
- Astrocyte-derived trophic factor antibody
see all
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (48)
ab18956 は 48 報の論文で使用されています。
- Zhao L et al. lncRNA SNHG17 promotes pancreatic carcinoma progression via cross-talking with miR-942. Am J Transl Res 13:1037-1050 (2021). PubMed: 33841638
- Liu J et al. Abnormal Glu/mGluR2/3/PI3K pathway in the hippocampal neurovascular unit leads to diabetes-related depression. Neural Regen Res 16:727-733 (2021). PubMed: 33063735
- Ucar B et al. Biomaterial based strategies to reconstruct the nigrostriatal pathway in organotypic slice co-cultures. Acta Biomater 121:250-262 (2021). PubMed: 33242639
- Cui W et al. CARF promotes spermatogonial self-renewal and proliferation through Wnt signaling pathway. Cell Discov 6:85 (2020). PubMed: 33298864
- Zhang H et al. Glycine-Histidine-Lysine (GHK) Alleviates Astrocytes Injury of Intracerebral Hemorrhage via the Akt/miR-146a-3p/AQP4 Pathway. Front Neurosci 14:576389 (2020). PubMed: 33192260