Key features and details
- Rabbit polyclonal to Gastrin
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Gastrin 一次抗体 製品一覧
製品の詳細Rabbit polyclonal to Gastrin
アプリケーション適用あり: IHC-Pmore details
交差が予測される動物種: Horse, Dog
Synthetic peptide within Human Gastrin aa 50 to the C-terminus. The exact sequence is proprietary.
Database link: P01350
- Pituitary or stomach
This antibody may be used to study the differential tissue expression and intracellular and subcellular localization of gastrin in neuroendocrine cells of the gastrointestinal tract, and in the CNS. Antibodies to gastrin are also useful for the identificationand detection of gastrin in normal and neoplastic tissue.
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保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Preservative: 0.1% Sodium azide
Constituents: PBS, 1% BSA
Concentration information loading...
精製度Immunogen affinity purified
一次抗体 備考This antibody may be used to study the differential tissue expression and intracellular and subcellular localization of gastrin in neuroendocrine cells of the gastrointestinal tract,and in the CNS. Antibodies to gastrin are also useful for the identificationand detection of gastrin in normal and neoplastic tissue.
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機能Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.
配列類似性Belongs to the gastrin/cholecystokinin family.
翻訳後修飾Two different processing pathways probably exist in antral G-cells. In the dominant pathway progastrin is cleaved at three sites resulting in two major bioactive gastrins, gastrin-34 and gastrin-17. In the putative alternative pathway, progastrin may be processed only at the most C-terminal dibasic site resulting in the synthesis of gastrin-71.
Sulfation enhances proteolytic processing, and blocks peptide degradation. Levels of sulfation differ between proteolytically-cleaved gastrins. Thus, gastrin-6 is almost 73% sulfated, whereas the larger gastrins are less than 50% sulfated. Sulfation levels are also tissue-specific.
- Information by UniProt
- Component II antibody
- G14 antibody
- G17 antibody
ab16035 は 1 報の論文で使用されています。
- Lennerz JK et al. The Transcription Factor MIST1 Is a Novel Human Gastric Chief Cell Marker Whose Expression Is Lost in Metaplasia, Dysplasia, and Carcinoma. Am J Pathol 177:1514-33 (2010). IHC-P ; Human . PubMed: 20709804