Key features and details
- Potent selective acetylcholinesterase inhibitor.
- CAS Number: 357-70-0
- Soluble in DMSO to 50 mM and in ethanol to 100 mM with gentle warming
- Form / State: Solid
- Source: Synthetic
製品名Galanthamine, cholinesterase inhibitor
製品の詳細Potent selective acetylcholinesterase inhibitor.
Potent selective acetylcholinesterase inhibitor (IC50 = 410 nM). Greater than 50-fold selective versus butyrylcholinesterase. Inhibits RBC cholinesterase activity 10-fold more potently than that of human brain tissue. Reduces apoptotic effect of thapsigargin in SH-SY5Y cells. Non-competitive nicotinic receptor aganist in rat PC12 cells. Neuroprotective following ischemia-reperfusion injury in animal models.
保存方法Shipped at room temperature. Store at -20°C.
溶解性Soluble in DMSO to 50 mM and in ethanol to 100 mM with gentle warming
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.