Anti-GABRB1 抗体 [EPR10343] (ab154822)
Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Rabbit monoclonal [EPR10343] to GABRB1
- Suitable for: WB
- Reacts with: Human
Related conjugates and formulations
製品の概要
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製品名
Anti-GABRB1 antibody [EPR10343]
GABRB1 一次抗体 製品一覧 -
製品の詳細
Rabbit monoclonal [EPR10343] to GABRB1 -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details
適用なし: ICC/IF,IHC-P or IP -
種交差性
交差種: Human
交差が予測される動物種: Mouse, Rat -
免疫原
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
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ポジティブ・コントロール
- Human cerebellum and fetal brain tissue lysates.
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特記事項
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free production
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at -20ºC. -
バッファー
pH: 7.2
Preservative: 0.01% Sodium azide
Constituents: 9% PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, 50% Tissue culture supernatant -
Concentration information loading...
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精製度
Protein A purified -
ポリ/モノ
モノクローナル -
クローン名
EPR10343 -
アイソタイプ
IgG -
研究分野
関連製品
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Alternative Versions
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab154822の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB |
1/1000 - 1/10000. Predicted molecular weight: 54 kDa.
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特記事項 |
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WB
1/1000 - 1/10000. Predicted molecular weight: 54 kDa. |
ターゲット情報
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機能
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. -
配列類似性
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRB1 sub-subfamily. -
細胞内局在
Cell junction > synapse > postsynaptic cell membrane. Cell membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 2560 Human
- Entrez Gene: 14400 Mouse
- Entrez Gene: 25450 Rat
- Omim: 137190 Human
- SwissProt: P18505 Human
- SwissProt: P50571 Mouse
- SwissProt: P15431 Rat
- Unigene: 27283 Human
see all -
別名
- AW061132 antibody
- B230208N19Rik antibody
- GABA(A) receptor beta 1 antibody
see all
画像
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (5)
ab154822 は 5 報の論文で使用されています。
- Hur KH et al. Mepirapim, a Novel Synthetic Cannabinoid, Induces Addiction-Related Behaviors through Neurochemical Maladaptation in the Brain of Rodents. Pharmaceuticals (Basel) 15:N/A (2022). PubMed: 35745629
- Pan B et al. Chronic antipsychotic treatment differentially modulates protein kinase A- and glycogen synthase kinase 3 beta-dependent signaling pathways, N-methyl-D-aspartate receptor and ?-aminobutyric acid A receptors in nucleus accumbens of juvenile rats. J Psychopharmacol 32:1252-1263 (2018). PubMed: 30136620
- Pan B et al. Aripiprazole Increases the PKA Signalling and Expression of the GABAA Receptor and CREB1 in the Nucleus Accumbens of Rats. J Mol Neurosci 59:36-47 (2016). PubMed: 26894264
- Kaneko Y et al. Oxytocin modulates GABAAR subunits to confer neuroprotection in stroke in vitro. Sci Rep 6:35659 (2016). WB ; Rat . PubMed: 27767042
- Pan B et al. Chronic administration of aripiprazole activates GSK3ß-dependent signalling pathways, and up-regulates GABAA receptor expression and CREB1 activity in rats. Sci Rep 6:30040 (2016). WB ; Rat . PubMed: 27435909