Anti-GABA A Receptor beta 2/GABRB2 抗体 [EPR10517] (ab156000)
Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Rabbit monoclonal [EPR10517] to GABA A Receptor beta 2/GABRB2
- Suitable for: WB
- Reacts with: Human
Related conjugates and formulations
製品の概要
-
製品名
Anti-GABA A Receptor beta 2/GABRB2 antibody [EPR10517]
GABA A Receptor beta 2/GABRB2 一次抗体 製品一覧 -
製品の詳細
Rabbit monoclonal [EPR10517] to GABA A Receptor beta 2/GABRB2 -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details
適用なし: Flow Cyt,ICC/IF,IHC-P or IP -
種交差性
交差種: Human
交差が予測される動物種: Mouse, Rat -
免疫原
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
-
ポジティブ・コントロール
- HepG2, A549, fetal brain and Human cerebellum lysates.
-
特記事項
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free production
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
製品の特性
-
製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at -20ºC. -
バッファー
pH: 7.2
Preservative: 0.01% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine), 0.5% BSA -
Concentration information loading...
-
精製度
Protein A purified -
ポリ/モノ
モノクローナル -
クローン名
EPR10517 -
アイソタイプ
IgG -
研究分野
関連製品
-
Alternative Versions
-
Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab156000の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
---|---|---|
WB |
1/10000 - 1/50000. Predicted molecular weight: 59 kDa.
|
特記事項 |
---|
WB
1/10000 - 1/50000. Predicted molecular weight: 59 kDa. |
ターゲット情報
-
機能
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. -
組織特異性
Isoform 1 and isoform 2 show reduced expression in schizophrenic brain. Isoform 3 shows increased expression in schizophrenic and bipolar disorder brains while isoform 4 shows reduced expression. -
配列類似性
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRB2 sub-subfamily. -
細胞内局在
Cell junction > synapse > postsynaptic cell membrane. Cell membrane. - Information by UniProt
-
参照データベース
- Entrez Gene: 2561 Human
- Entrez Gene: 14401 Mouse
- Entrez Gene: 25451 Rat
- Omim: 600232 Human
- SwissProt: P47870 Human
- SwissProt: P63137 Mouse
- SwissProt: P63138 Rat
- Unigene: 303527 Human
see all -
別名
- GABA antibody
- GABA(A) receptor beta 2 antibody
- GABA(A) receptor subunit beta-2 antibody
see all
画像
-
All lanes : Anti-GABA A Receptor beta 2/GABRB2 antibody [EPR10517] (ab156000) at 1/10000 dilution
Lane 1 : HepG2 cell lysate
Lane 2 : A549 cell lysate
Lane 3 : Fetal brain lysate
Lane 4 : Human cerebellum lysate
Lysates/proteins at 10 µg per lane.
Secondary
All lanes : HRP labelled goat anti-rabbit at 1/2000 dilution
Predicted band size: 59 kDa
データシートおよび資料
-
SDS download
-
Datasheet download
参考文献 (10)
ab156000 は 10 報の論文で使用されています。
- Chen M et al. Enhancing GABAergic signaling ameliorates aberrant gamma oscillations of olfactory bulb in AD mouse models. Mol Neurodegener 16:14 (2021). PubMed: 33663578
- Kreuzer M et al. Sleep/Wake Behavior and EEG Signatures of the TgF344-AD Rat Model at the Prodromal Stage. Int J Mol Sci 21:N/A (2020). PubMed: 33291462
- Speigel IA et al. Chronic Calcineurin Inhibition via Cyclosporine A Impairs Visuospatial Learning After Isoflurane Anesthesia. Anesth Analg 129:192-203 (2019). PubMed: 31082969
- Zhang K et al. CB1 agonism prolongs therapeutic window for hormone replacement in ovariectomized mice. J Clin Invest 129:2333-2350 (2019). PubMed: 31063987
- Andrés-Benito P et al. Gene Expression Profile in Frontal Cortex in Sporadic Frontotemporal Lobar Degeneration-TDP. J Neuropathol Exp Neurol 77:608-627 (2018). PubMed: 29788265
- Chen M et al. APP modulates KCC2 expression and function in hippocampal GABAergic inhibition. Elife 6:N/A (2017). WB ; Mouse . PubMed: 28054918
- Pan B et al. Chronic administration of aripiprazole activates GSK3ß-dependent signalling pathways, and up-regulates GABAA receptor expression and CREB1 activity in rats. Sci Rep 6:30040 (2016). WB ; Rat . PubMed: 27435909
- Tjomsland V et al. Profile of MMP and TIMP Expression in Human Pancreatic Stellate Cells: Regulation by IL-1a and TGFß and Implications for Migration of Pancreatic Cancer Cells. Neoplasia 18:447-56 (2016). IHC-P ; Human . PubMed: 27435927
- Kaneko Y et al. Oxytocin modulates GABAAR subunits to confer neuroprotection in stroke in vitro. Sci Rep 6:35659 (2016). WB ; Rat . PubMed: 27767042
- Pan B et al. Aripiprazole Increases the PKA Signalling and Expression of the GABAA Receptor and CREB1 in the Nucleus Accumbens of Rats. J Mol Neurosci 59:36-47 (2016). PubMed: 26894264